Acid sphingomyelinase inhibition improves motor behavioral deficits and neuronal loss in an amyotrophic lateral sclerosis mouse model

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the degeneration of motor neurons in the spinal cord. Main symptoms are manifested as weakness, muscle loss, and muscle atrophy. Some studies have reported that alterations in sphingolipid metabolism may b...

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Detalles Bibliográficos
Autores principales: Choi, Byung Jo, Park, Kang Ho, Park, Min Hee, Huang, Eric Jinsheng, Kim, Seung Hyun, Bae, Jae-sung, Jin, Hee Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813424/
https://www.ncbi.nlm.nih.gov/pubmed/36229415
http://dx.doi.org/10.5483/BMBRep.2022.55.12.142

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