Selective cytotoxicity of a novel mitochondrial complex I inhibitor, YK-135, against EMT-subtype gastric cancer cell lines due to impaired glycolytic capacity

Epithelial-to-mesenchymal transition (EMT)-subtype gastric cancers have the worst prognosis due to their higher recurrence rate, higher probability of developing metastases and higher chemo-resistance compared to those of other molecular subtypes. Pharmacologically actionable somatic mutations are r...

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Detalles Bibliográficos
Autores principales: Sung, Yeojin, Cha, Seungbin, Kim, Sang Bum, Kim, Hakhyun, Choi, Seonghwi, Oh, Sejin, Kim, Minseo, Lee, Yunji, Kwon, Gino, Lee, Jooyoung, Lee, Joo-Youn, Han, Gyoonhee, Kim, Hyun Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813428/
https://www.ncbi.nlm.nih.gov/pubmed/36379512
http://dx.doi.org/10.5483/BMBRep.2022.55.12.150

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