Hindering NAT8L expression in hepatocellular carcinoma increases cytosolic aspartate delivery that fosters pentose phosphate pathway and purine biosynthesis promoting cell proliferation

N-acetylaspartate (NAA) is synthesized by the mitochondrial enzyme NAT8L, which uses acetyl-CoA and aspartate as substrates. These metabolites are fundamental for bioenergetics and anabolic requirements of highly proliferating cells, thus, NAT8L modulation may impinge on the metabolic reprogramming...

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Detalles Bibliográficos
Autores principales: De Falco, Pamela, Lazzarino, Giacomo, Felice, Federica, Desideri, Enrico, Castelli, Serena, Salvatori, Illari, Ciccarone, Fabio, Ciriolo, Maria Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813579/
https://www.ncbi.nlm.nih.gov/pubmed/36580805
http://dx.doi.org/10.1016/j.redox.2022.102585

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