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Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI

Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume. Thirty-one female and 32 male genetic SVD (cerebral autos...

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Autores principales: Jia, Xiuqin, Ling, Chen, Li, Yingying, Zhang, Jinyuan, Li, Zhixin, Jia, Xuejia, Wang, Danny J.J., Zhang, Zihao, Yuan, Yun, Yang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813786/
https://www.ncbi.nlm.nih.gov/pubmed/36577270
http://dx.doi.org/10.1016/j.nicl.2022.103298
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author Jia, Xiuqin
Ling, Chen
Li, Yingying
Zhang, Jinyuan
Li, Zhixin
Jia, Xuejia
Wang, Danny J.J.
Zhang, Zihao
Yuan, Yun
Yang, Qi
author_facet Jia, Xiuqin
Ling, Chen
Li, Yingying
Zhang, Jinyuan
Li, Zhixin
Jia, Xuejia
Wang, Danny J.J.
Zhang, Zihao
Yuan, Yun
Yang, Qi
author_sort Jia, Xiuqin
collection PubMed
description Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume. Thirty-one female and 32 male genetic SVD (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL) patients and 55 sex- and age-matched healthy controls (HCs) underwent 7-Tesla MRI examinations. Voxel-based W-score maps were calculated from volumes and deformations of brain tissues, controlling for the expected effects of age and sex in HCs. Significant cognitive declines in working memory and executive function were identified in male CADASIL patients compared to female patients. Greater gray matter (GM) atrophy was found in the bilateral orbitofrontal cortex (OFC), left anterior cingulate cortex (ACC), left entorhinal cortex (EC), and right temporooccipital cortex in male CADASIL patients than in females. Working memory was associated with volumes in the right OFC specific to female CADASIL patients, whereas visuospatial ability was associated with the right hOcl (primary visual area, BA 17) volume specific to males. The current findings indicate that sex affects the pathogenesis of CADASIL, ranging from differences in neuroanatomy to those in behavioral performance, which may facilitate the development of more effective sex-specific therapeutic strategies for CADASIL and SVD.
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spelling pubmed-98137862023-01-06 Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI Jia, Xiuqin Ling, Chen Li, Yingying Zhang, Jinyuan Li, Zhixin Jia, Xuejia Wang, Danny J.J. Zhang, Zihao Yuan, Yun Yang, Qi Neuroimage Clin Regular Article Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume. Thirty-one female and 32 male genetic SVD (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL) patients and 55 sex- and age-matched healthy controls (HCs) underwent 7-Tesla MRI examinations. Voxel-based W-score maps were calculated from volumes and deformations of brain tissues, controlling for the expected effects of age and sex in HCs. Significant cognitive declines in working memory and executive function were identified in male CADASIL patients compared to female patients. Greater gray matter (GM) atrophy was found in the bilateral orbitofrontal cortex (OFC), left anterior cingulate cortex (ACC), left entorhinal cortex (EC), and right temporooccipital cortex in male CADASIL patients than in females. Working memory was associated with volumes in the right OFC specific to female CADASIL patients, whereas visuospatial ability was associated with the right hOcl (primary visual area, BA 17) volume specific to males. The current findings indicate that sex affects the pathogenesis of CADASIL, ranging from differences in neuroanatomy to those in behavioral performance, which may facilitate the development of more effective sex-specific therapeutic strategies for CADASIL and SVD. Elsevier 2022-12-21 /pmc/articles/PMC9813786/ /pubmed/36577270 http://dx.doi.org/10.1016/j.nicl.2022.103298 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Jia, Xiuqin
Ling, Chen
Li, Yingying
Zhang, Jinyuan
Li, Zhixin
Jia, Xuejia
Wang, Danny J.J.
Zhang, Zihao
Yuan, Yun
Yang, Qi
Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI
title Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI
title_full Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI
title_fullStr Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI
title_full_unstemmed Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI
title_short Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI
title_sort sex differences in frontotemporal atrophy in cadasil revealed by 7-tesla mri
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813786/
https://www.ncbi.nlm.nih.gov/pubmed/36577270
http://dx.doi.org/10.1016/j.nicl.2022.103298
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