EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

The cancer metastasis process involves dysregulated oncogenic kinase signaling, but how this orchestrates metabolic networks and signal cascades to promote metastasis is largely unclear. Here we report that inhibition of glutamate dehydrogenase 1 (GDH1) and ribosomal S6 kinase 2 (RSK2) synergistical...

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Detalles Bibliográficos
Autores principales: Kang, JiHoon, Chun, Jaemoo, Hwang, Jung Seok, Pan, Chaoyun, Li, Jie, Boese, Austin C., Young, Isabelle, Malin, Courteney M., Kang, Yibin, Gibbons, Don L., Sica, Gabriel, Fu, Haian, Ramalingam, Suresh S., Jin, Lingtao, Kang, Sumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813823/
https://www.ncbi.nlm.nih.gov/pubmed/36516759
http://dx.doi.org/10.1016/j.celrep.2022.111827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813823/
https://www.ncbi.nlm.nih.gov/pubmed/36516759
http://dx.doi.org/10.1016/j.celrep.2022.111827

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