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PIK3CA mutations are associated with pathologic complete response rate to neoadjuvant pyrotinib and trastuzumab plus chemotherapy for HER2-positive breast cancer

BACKGROUND: Neoadjuvant treatment with a dual anti-human epidermal growth factor receptor 2 (HER2) blockade with pyrotinib and trastuzumab has been shown to be effective for HER2-positive breast cancer. METHODS: The genomic characteristics of 425 cancer-related genes from the archived tumour blocks...

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Detalles Bibliográficos
Autores principales:	Shi, Qiyun, Xuhong, Juncheng, Luo, Tao, Ge, Jia, Liu, Feng, Lan, Yang, Chen, Qingqiu, Tang, Peng, Fan, Linjun, Chen, Li, Liang, Yan, Wang, Minghao, Hu, Ying, Zhang, Yi, Bian, Xiuwu, Qi, Xiaowei, Jiang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814131/ https://www.ncbi.nlm.nih.gov/pubmed/36323880 http://dx.doi.org/10.1038/s41416-022-02021-z

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