Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and expand the potential for microglia replacement, we engineered an inhibitor-resistant CSF1R that enables robust microglia repl...

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Detalles Bibliográficos
Autores principales: Chadarevian, Jean Paul, Lombroso, Sonia I., Peet, Graham C., Hasselmann, Jonathan, Tu, Christina, Marzan, Dave E., Capocchi, Joia, Purnell, Freddy S., Nemec, Kelsey M., Lahian, Alina, Escobar, Adrian, England, Whitney, Chaluvadi, Sai, O’Brien, Carleigh A., Yaqoob, Fazeela, Aisenberg, William H., Porras-Paniagua, Matias, Bennett, Mariko L., Davtyan, Hayk, Spitale, Robert C., Blurton-Jones, Mathew, Bennett, F. Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814156/
https://www.ncbi.nlm.nih.gov/pubmed/36584406
http://dx.doi.org/10.1084/jem.20220857

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