Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors

BACKGROUND: Perioperative neurocognitive disorders (PND) with a high incidence frequently occur in elderly surgical patients closely associated with prolonged anesthesia-induced neurotoxicity. The neuromorphopathological underpinnings of anesthesia-induced neurotoxicity have remained elusive. METHOD...

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Detalles Bibliográficos
Autores principales: Xu, Feng, Han, Linlin, Wang, Yafeng, Deng, Daling, Ding, Yuanyuan, Zhao, Shuai, Zhang, Qingtong, Ma, Lulin, Chen, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814183/
https://www.ncbi.nlm.nih.gov/pubmed/36600274
http://dx.doi.org/10.1186/s12916-022-02705-6

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