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Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients
BACKGROUND AND PURPOSE: Mild cognitive impairment is an age-dependent pre-dementia state caused by varied reasons. Early detection of MCI helps handle dementia. Vascular factors are vital for the occurrence of MCI. This study investigates the correlation between deep medullary veins and multi-dimens...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814341/ https://www.ncbi.nlm.nih.gov/pubmed/36604624 http://dx.doi.org/10.1186/s12883-022-03037-x |
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author | Chen, Xiuqi Luo, Yufan Zhang, Shufan Yang, Xiaoli Dong, Zhiyuan Wang, Yilin Wu, Danhong |
author_facet | Chen, Xiuqi Luo, Yufan Zhang, Shufan Yang, Xiaoli Dong, Zhiyuan Wang, Yilin Wu, Danhong |
author_sort | Chen, Xiuqi |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Mild cognitive impairment is an age-dependent pre-dementia state caused by varied reasons. Early detection of MCI helps handle dementia. Vascular factors are vital for the occurrence of MCI. This study investigates the correlation between deep medullary veins and multi-dimensional cognitive outcomes. MATERIALS AND METHODS: A total of 73 participants with MCI and 32 controls were enrolled. Minimum Mental State Examination and Montreal Cognitive Assessment were used to examine the global cognitive function, and different cognitive domains were measured by specific neuropsychological tests. MRI was used to assess the visibility of the DMV and other neuroimage markers. RESULTS: DMV score was statistically significantly higher in the MCI group compared with the control group (P = 0.009) and independently related to MCI (P = 0.007). Linear regression analysis verified that DMV score was linearly related to global cognition, memory, attention, and executive function after adjusting for cerebrovascular risk factors. CONCLUSION: DMV score was independently related to the onset of MCI, and correlates with overall cognition, memory, attention, and executive function in outpatients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-022-03037-x. |
format | Online Article Text |
id | pubmed-9814341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98143412023-01-06 Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients Chen, Xiuqi Luo, Yufan Zhang, Shufan Yang, Xiaoli Dong, Zhiyuan Wang, Yilin Wu, Danhong BMC Neurol Research BACKGROUND AND PURPOSE: Mild cognitive impairment is an age-dependent pre-dementia state caused by varied reasons. Early detection of MCI helps handle dementia. Vascular factors are vital for the occurrence of MCI. This study investigates the correlation between deep medullary veins and multi-dimensional cognitive outcomes. MATERIALS AND METHODS: A total of 73 participants with MCI and 32 controls were enrolled. Minimum Mental State Examination and Montreal Cognitive Assessment were used to examine the global cognitive function, and different cognitive domains were measured by specific neuropsychological tests. MRI was used to assess the visibility of the DMV and other neuroimage markers. RESULTS: DMV score was statistically significantly higher in the MCI group compared with the control group (P = 0.009) and independently related to MCI (P = 0.007). Linear regression analysis verified that DMV score was linearly related to global cognition, memory, attention, and executive function after adjusting for cerebrovascular risk factors. CONCLUSION: DMV score was independently related to the onset of MCI, and correlates with overall cognition, memory, attention, and executive function in outpatients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-022-03037-x. BioMed Central 2023-01-05 /pmc/articles/PMC9814341/ /pubmed/36604624 http://dx.doi.org/10.1186/s12883-022-03037-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Chen, Xiuqi Luo, Yufan Zhang, Shufan Yang, Xiaoli Dong, Zhiyuan Wang, Yilin Wu, Danhong Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients |
title | Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients |
title_full | Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients |
title_fullStr | Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients |
title_full_unstemmed | Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients |
title_short | Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients |
title_sort | deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814341/ https://www.ncbi.nlm.nih.gov/pubmed/36604624 http://dx.doi.org/10.1186/s12883-022-03037-x |
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