Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

Biosensor techniques have become increasingly important for fragment-based drug discovery during the last years. The AAA+ ATPase p97 is an essential protein with key roles in protein homeostasis and a possible target for cancer chemotherapy. Currently available p97 inhibitors address its ATPase acti...

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Detalles Bibliográficos
Autores principales: Bothe, Sebastian, Hänzelmann, Petra, Böhler, Stephan, Kehrein, Josef, Zehe, Markus, Wiedemann, Christoph, Hellmich, Ute A., Brenk, Ruth, Schindelin, Hermann, Sotriffer, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814400/
https://www.ncbi.nlm.nih.gov/pubmed/36697690
http://dx.doi.org/10.1038/s42004-022-00782-5

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