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Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island

BACKGROUND: Tuberculosis is the first fatal infectious agent in the world with 1.2 million annual deaths for 10 million cases. Little is known about the epidemiology of tuberculosis and its resistance in Reunion Island, which is at the heart of migratory flows from highly endemic Indian Ocean territ...

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Autores principales: Loukman, Moreea, Olivier, Belmonte, Vincent, Boulay, Rachid, Dekkak, Cyril, Ferdynus, Morgane, Verduyn, Nathalie, Coolen-Allou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814425/
https://www.ncbi.nlm.nih.gov/pubmed/36604621
http://dx.doi.org/10.1186/s12879-022-07965-4
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author Loukman, Moreea
Olivier, Belmonte
Vincent, Boulay
Rachid, Dekkak
Cyril, Ferdynus
Morgane, Verduyn
Nathalie, Coolen-Allou
author_facet Loukman, Moreea
Olivier, Belmonte
Vincent, Boulay
Rachid, Dekkak
Cyril, Ferdynus
Morgane, Verduyn
Nathalie, Coolen-Allou
author_sort Loukman, Moreea
collection PubMed
description BACKGROUND: Tuberculosis is the first fatal infectious agent in the world with 1.2 million annual deaths for 10 million cases. Little is known about the epidemiology of tuberculosis and its resistance in Reunion Island, which is at the heart of migratory flows from highly endemic Indian Ocean territories. METHODS: We carried out a retrospective observational study of cases of tuberculosis disease in Reunion Island between 2014 and 2018. The epidemiological, demographic, microbiological, clinical and social characteristics were analyzed from mandatory declarations, microbiology database and medical files. RESULTS: 265 cases of tuberculosis disease were recorded over the period, ie an incidence of 6.2 / 100,000 inhabitants. 114 patients (43%) were born or resided > 6 months in the rest of the Indian Ocean area. The risk of infection was increased if birth in Madagascar (OR 23.5), Comoros (OR 8.9) or Mayotte (OR 6.8). The prevalence of HIV co-infection was low (2.5%). There were 31 cases (14.4%) of resistance to antituberculosis including 3 (1.4%) of multidrug-resistant tuberculosis and 0 case of extensively drug-resistant tuberculosis. The female gender (61.3% of resistant) was associated with resistance. The resistance rate was not significantly different depending on the geographic origin. CONCLUSION: This is the first exhaustive epidemiological study of tuberculosis in Reunion Island. The incidence there is relatively low but increased for people with links to neighboring islands, particularly Madagascar. The prevalence of multidrug resistance is low, with no associated increased risk for patients from the Indian Ocean area.
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spelling pubmed-98144252023-01-06 Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island Loukman, Moreea Olivier, Belmonte Vincent, Boulay Rachid, Dekkak Cyril, Ferdynus Morgane, Verduyn Nathalie, Coolen-Allou BMC Infect Dis Research BACKGROUND: Tuberculosis is the first fatal infectious agent in the world with 1.2 million annual deaths for 10 million cases. Little is known about the epidemiology of tuberculosis and its resistance in Reunion Island, which is at the heart of migratory flows from highly endemic Indian Ocean territories. METHODS: We carried out a retrospective observational study of cases of tuberculosis disease in Reunion Island between 2014 and 2018. The epidemiological, demographic, microbiological, clinical and social characteristics were analyzed from mandatory declarations, microbiology database and medical files. RESULTS: 265 cases of tuberculosis disease were recorded over the period, ie an incidence of 6.2 / 100,000 inhabitants. 114 patients (43%) were born or resided > 6 months in the rest of the Indian Ocean area. The risk of infection was increased if birth in Madagascar (OR 23.5), Comoros (OR 8.9) or Mayotte (OR 6.8). The prevalence of HIV co-infection was low (2.5%). There were 31 cases (14.4%) of resistance to antituberculosis including 3 (1.4%) of multidrug-resistant tuberculosis and 0 case of extensively drug-resistant tuberculosis. The female gender (61.3% of resistant) was associated with resistance. The resistance rate was not significantly different depending on the geographic origin. CONCLUSION: This is the first exhaustive epidemiological study of tuberculosis in Reunion Island. The incidence there is relatively low but increased for people with links to neighboring islands, particularly Madagascar. The prevalence of multidrug resistance is low, with no associated increased risk for patients from the Indian Ocean area. BioMed Central 2023-01-05 /pmc/articles/PMC9814425/ /pubmed/36604621 http://dx.doi.org/10.1186/s12879-022-07965-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Loukman, Moreea
Olivier, Belmonte
Vincent, Boulay
Rachid, Dekkak
Cyril, Ferdynus
Morgane, Verduyn
Nathalie, Coolen-Allou
Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island
title Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island
title_full Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island
title_fullStr Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island
title_full_unstemmed Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island
title_short Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island
title_sort epidemiology of tuberculosis and susceptibility to antituberculosis drugs in reunion island
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814425/
https://www.ncbi.nlm.nih.gov/pubmed/36604621
http://dx.doi.org/10.1186/s12879-022-07965-4
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