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Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers
Understanding and controlling the interaction between nanoparticles and biological entities is fundamental to the development of nanomedicine applications. In particular, the possibility to realize nanoparticles capable of directly targeting neutral lipid membranes would be advantageous to numerous...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814519/ https://www.ncbi.nlm.nih.gov/pubmed/36697571 http://dx.doi.org/10.1038/s42004-021-00526-x |
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author | Morillas-Becerril, Lucía Franco-Ulloa, Sebastian Fortunati, Ilaria Marotta, Roberto Sun, Xiaohuan Zanoni, Giordano De Vivo, Marco Mancin, Fabrizio |
author_facet | Morillas-Becerril, Lucía Franco-Ulloa, Sebastian Fortunati, Ilaria Marotta, Roberto Sun, Xiaohuan Zanoni, Giordano De Vivo, Marco Mancin, Fabrizio |
author_sort | Morillas-Becerril, Lucía |
collection | PubMed |
description | Understanding and controlling the interaction between nanoparticles and biological entities is fundamental to the development of nanomedicine applications. In particular, the possibility to realize nanoparticles capable of directly targeting neutral lipid membranes would be advantageous to numerous applications aiming at delivering nanoparticles and their cargos into cells and biological vesicles. Here, we use experimental and computational methodologies to analyze the interaction between liposomes and gold nanoparticles (AuNPs) featuring cationic headgroups in their protecting monolayer. We find that in contrast to nanoparticles decorated with other positively charged headgroups, guanidinium-coated AuNPs can bind to neutral phosphatidylcholine liposomes, inducing nondisruptive membrane permeabilization. Atomistic molecular simulations reveal that this ability is due to the multivalent H-bonding interaction between the phosphate residues of the liposome’s phospholipids and the guanidinium groups. Our results demonstrate that the peculiar properties of arginine magic, an effect responsible for the membranotropic properties of some naturally occurring peptides, are also displayed by guanidinium-bearing functionalized AuNPs. |
format | Online Article Text |
id | pubmed-9814519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98145192023-01-10 Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers Morillas-Becerril, Lucía Franco-Ulloa, Sebastian Fortunati, Ilaria Marotta, Roberto Sun, Xiaohuan Zanoni, Giordano De Vivo, Marco Mancin, Fabrizio Commun Chem Article Understanding and controlling the interaction between nanoparticles and biological entities is fundamental to the development of nanomedicine applications. In particular, the possibility to realize nanoparticles capable of directly targeting neutral lipid membranes would be advantageous to numerous applications aiming at delivering nanoparticles and their cargos into cells and biological vesicles. Here, we use experimental and computational methodologies to analyze the interaction between liposomes and gold nanoparticles (AuNPs) featuring cationic headgroups in their protecting monolayer. We find that in contrast to nanoparticles decorated with other positively charged headgroups, guanidinium-coated AuNPs can bind to neutral phosphatidylcholine liposomes, inducing nondisruptive membrane permeabilization. Atomistic molecular simulations reveal that this ability is due to the multivalent H-bonding interaction between the phosphate residues of the liposome’s phospholipids and the guanidinium groups. Our results demonstrate that the peculiar properties of arginine magic, an effect responsible for the membranotropic properties of some naturally occurring peptides, are also displayed by guanidinium-bearing functionalized AuNPs. Nature Publishing Group UK 2021-06-18 /pmc/articles/PMC9814519/ /pubmed/36697571 http://dx.doi.org/10.1038/s42004-021-00526-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Morillas-Becerril, Lucía Franco-Ulloa, Sebastian Fortunati, Ilaria Marotta, Roberto Sun, Xiaohuan Zanoni, Giordano De Vivo, Marco Mancin, Fabrizio Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers |
title | Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers |
title_full | Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers |
title_fullStr | Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers |
title_full_unstemmed | Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers |
title_short | Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers |
title_sort | specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814519/ https://www.ncbi.nlm.nih.gov/pubmed/36697571 http://dx.doi.org/10.1038/s42004-021-00526-x |
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