Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform

Glycine-alanine dipeptide repeats (GA DPRs) translated from the mutated C9orf72 gene have recently been correlated with amyotrophic lateral sclerosis (ALS). While GA DPRs aggregates have been suggested as amyloid, the biophysical features and cytotoxicity of GA DPRs oligomers has not been explored d...

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Detalles Bibliográficos
Autores principales: Chien, Hung-Ming, He, Ruei-Yu, Lee, Chi-Chang, Huang, Yung-An, Hung, I-Ju, Hou, Kai-Ting, Hsiao, Jye-Chian, Lu, Po-Chao, Agnihotri, Diksha, Hwang, Eric, Huang, Joseph Jen-Tse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814621/
https://www.ncbi.nlm.nih.gov/pubmed/36697556
http://dx.doi.org/10.1038/s42004-021-00547-6

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