Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input

Bioconjugation reactions play a central facilitating role in engendering modified peptides and proteins. Early progress in this area was inhibited by challenges such as the limited range of substrates and the relatively poor biocompatibility of bioconjugation reagents. However, the recent developmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Weng, Yue, Song, Chunlan, Chiang, Chien-Wei, Lei, Aiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814624/
https://www.ncbi.nlm.nih.gov/pubmed/36703459
http://dx.doi.org/10.1038/s42004-020-00413-x
_version_ 1784864176832774144
author Weng, Yue
Song, Chunlan
Chiang, Chien-Wei
Lei, Aiwen
author_facet Weng, Yue
Song, Chunlan
Chiang, Chien-Wei
Lei, Aiwen
author_sort Weng, Yue
collection PubMed
description Bioconjugation reactions play a central facilitating role in engendering modified peptides and proteins. Early progress in this area was inhibited by challenges such as the limited range of substrates and the relatively poor biocompatibility of bioconjugation reagents. However, the recent developments in visible-light induced photoredox catalysis and electrochemical catalysis reactions have permitted significant novel reactivities to be developed in the field of synthetic and bioconjugation chemistry. This perspective describes recent advances in the use of biocompatible energy input for the modification of peptides and proteins mainly, via the single electron transfer (SET) process, as well as key future developments in this area.
format Online
Article
Text
id pubmed-9814624
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-98146242023-01-10 Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input Weng, Yue Song, Chunlan Chiang, Chien-Wei Lei, Aiwen Commun Chem Perspective Bioconjugation reactions play a central facilitating role in engendering modified peptides and proteins. Early progress in this area was inhibited by challenges such as the limited range of substrates and the relatively poor biocompatibility of bioconjugation reagents. However, the recent developments in visible-light induced photoredox catalysis and electrochemical catalysis reactions have permitted significant novel reactivities to be developed in the field of synthetic and bioconjugation chemistry. This perspective describes recent advances in the use of biocompatible energy input for the modification of peptides and proteins mainly, via the single electron transfer (SET) process, as well as key future developments in this area. Nature Publishing Group UK 2020-11-13 /pmc/articles/PMC9814624/ /pubmed/36703459 http://dx.doi.org/10.1038/s42004-020-00413-x Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Weng, Yue
Song, Chunlan
Chiang, Chien-Wei
Lei, Aiwen
Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
title Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
title_full Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
title_fullStr Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
title_full_unstemmed Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
title_short Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
title_sort single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814624/
https://www.ncbi.nlm.nih.gov/pubmed/36703459
http://dx.doi.org/10.1038/s42004-020-00413-x
work_keys_str_mv AT wengyue singleelectrontransferbasedpeptideproteinbioconjugationsdrivenbybiocompatibleenergyinput
AT songchunlan singleelectrontransferbasedpeptideproteinbioconjugationsdrivenbybiocompatibleenergyinput
AT chiangchienwei singleelectrontransferbasedpeptideproteinbioconjugationsdrivenbybiocompatibleenergyinput
AT leiaiwen singleelectrontransferbasedpeptideproteinbioconjugationsdrivenbybiocompatibleenergyinput

Ejemplares similares