β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin

Caprazamycin is a nucleoside antibiotic that inhibits phospho-N-acetylmuramyl-pentapeptide translocase (MraY). The biosynthesis of nucleoside antibiotics has been studied but is still far from completion. The present study characterized enzymes Cpz10, Cpz15, Cpz27, Mur17, Mur23 out of caprazamycin/m...

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Detalles Bibliográficos
Autores principales: Zadeh, Saeid Malek, Chen, Mei-Hua, Wang, Zhe-Chong, Astani, Elahe K., Lo, I-Wen, Lin, Kuan-Hung, Hsu, Ning-Shian, Adhikari, Kamal, Lyu, Syue-Yi, Tsai, Hsin-Ying, Terasawa, Yuma, Yabe, Miyuki, Yamamoto, Kazuki, Ichikawa, Satoshi, Li, Tsung-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814697/
https://www.ncbi.nlm.nih.gov/pubmed/36697788
http://dx.doi.org/10.1038/s42004-022-00703-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814697/
https://www.ncbi.nlm.nih.gov/pubmed/36697788
http://dx.doi.org/10.1038/s42004-022-00703-6

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