Asymmetric C(sp(3))–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts

Benzylic functionalisation of unactivated alkylarenes remains as a significant challenge in asymmetric catalysis due to their less reactive nature. Here, we show development of catalytic asymmetric C(sp(3))–H functionalization of unactivated alkylarenes such as toluene with imines. The reactions pro...

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Detalles Bibliográficos
Autores principales: Hirata, Tsubasa, Sato, Io, Yamashita, Yasuhiro, Kobayashi, Shū
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814754/
https://www.ncbi.nlm.nih.gov/pubmed/36697525
http://dx.doi.org/10.1038/s42004-021-00459-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814754/
https://www.ncbi.nlm.nih.gov/pubmed/36697525
http://dx.doi.org/10.1038/s42004-021-00459-5

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