A human protein hydroxylase that accepts D-residues

Factor inhibiting hypoxia-inducible factor (FIH) is a 2-oxoglutarate-dependent protein hydroxylase that catalyses C3 hydroxylations of protein residues. We report FIH can accept (D)- and (L)-residues for hydroxylation. The substrate selectivity of FIH differs for (D) and (L) epimers, e.g., (D)- but...

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Detalles Bibliográficos
Autores principales: Choi, Hwanho, Hardy, Adam P., Leissing, Thomas M., Chowdhury, Rasheduzzaman, Nakashima, Yu, Ge, Wei, Markoulides, Marios, Scotti, John S., Gerken, Philip A., Thorbjornsrud, Helen, Kang, Dahye, Hong, Sungwoo, Lee, Joongoo, McDonough, Michael A., Park, Hwangseo, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814778/
https://www.ncbi.nlm.nih.gov/pubmed/36703414
http://dx.doi.org/10.1038/s42004-020-0290-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814778/
https://www.ncbi.nlm.nih.gov/pubmed/36703414
http://dx.doi.org/10.1038/s42004-020-0290-5

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