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Structure-based design of a dual-warhead covalent inhibitor of FGFR4

The fibroblast growth factor 19 (FGF19)/fibroblast growth factor receptor 4 (FGFR4) signaling pathways play critical roles in a variety of cancers, such as hepatocellular carcinoma (HCC). FGFR4 is recognized as a promising target to treat HCC. Currently, all FGFR covalent inhibitors target one of th...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaojuan, Li, Huiliang, Lin, Qianmeng, Dai, Shuyan, Yue, Sitong, Qu, Lingzhi, Li, Maoyu, Guo, Ming, Wei, Hudie, Li, Jun, Jiang, Longying, Xu, Guangyu, Chen, Yongheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814781/ https://www.ncbi.nlm.nih.gov/pubmed/36697897 http://dx.doi.org/10.1038/s42004-022-00657-9

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