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Unforeseen crystal forms of the natural osmolyte floridoside
Floridoside (2-α-O-D-galactopyranosyl glycerol) is a glycerol glycoside that is biosynthesised by most species of red algae and has been implicated as an intracellular regulator of various homeostatic functions. Here, we report the identification of two unforeseen crystal forms of the ubiquitous nat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814874/ https://www.ncbi.nlm.nih.gov/pubmed/36703387 http://dx.doi.org/10.1038/s42004-020-00376-z |
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author | Maneffa, Andrew J. Whitwood, Adrian C. Whitehouse, A. Steve Powell, Hugh Clark, James H. Matharu, Avtar S. |
author_facet | Maneffa, Andrew J. Whitwood, Adrian C. Whitehouse, A. Steve Powell, Hugh Clark, James H. Matharu, Avtar S. |
author_sort | Maneffa, Andrew J. |
collection | PubMed |
description | Floridoside (2-α-O-D-galactopyranosyl glycerol) is a glycerol glycoside that is biosynthesised by most species of red algae and has been implicated as an intracellular regulator of various homeostatic functions. Here, we report the identification of two unforeseen crystal forms of the ubiquitous natural osmolyte floridoside including a seemingly unheralded second anhydrous conformational polymorph and the unambiguous description of an elusive monohydrated variant. By employing a variety of thermal and spectroscopic techniques, we begin to explore both their macro and molecular physicochemical properties, which are notably different to that of the previously reported polymorph. This work advances the characterisation of this important natural biomolecule which could aid in facilitating optimised utilisation across a variety of anthropocentric applications and improve comprehension of its role in-vivo as a preeminent compatible solute. |
format | Online Article Text |
id | pubmed-9814874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98148742023-01-10 Unforeseen crystal forms of the natural osmolyte floridoside Maneffa, Andrew J. Whitwood, Adrian C. Whitehouse, A. Steve Powell, Hugh Clark, James H. Matharu, Avtar S. Commun Chem Article Floridoside (2-α-O-D-galactopyranosyl glycerol) is a glycerol glycoside that is biosynthesised by most species of red algae and has been implicated as an intracellular regulator of various homeostatic functions. Here, we report the identification of two unforeseen crystal forms of the ubiquitous natural osmolyte floridoside including a seemingly unheralded second anhydrous conformational polymorph and the unambiguous description of an elusive monohydrated variant. By employing a variety of thermal and spectroscopic techniques, we begin to explore both their macro and molecular physicochemical properties, which are notably different to that of the previously reported polymorph. This work advances the characterisation of this important natural biomolecule which could aid in facilitating optimised utilisation across a variety of anthropocentric applications and improve comprehension of its role in-vivo as a preeminent compatible solute. Nature Publishing Group UK 2020-09-11 /pmc/articles/PMC9814874/ /pubmed/36703387 http://dx.doi.org/10.1038/s42004-020-00376-z Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Maneffa, Andrew J. Whitwood, Adrian C. Whitehouse, A. Steve Powell, Hugh Clark, James H. Matharu, Avtar S. Unforeseen crystal forms of the natural osmolyte floridoside |
title | Unforeseen crystal forms of the natural osmolyte floridoside |
title_full | Unforeseen crystal forms of the natural osmolyte floridoside |
title_fullStr | Unforeseen crystal forms of the natural osmolyte floridoside |
title_full_unstemmed | Unforeseen crystal forms of the natural osmolyte floridoside |
title_short | Unforeseen crystal forms of the natural osmolyte floridoside |
title_sort | unforeseen crystal forms of the natural osmolyte floridoside |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814874/ https://www.ncbi.nlm.nih.gov/pubmed/36703387 http://dx.doi.org/10.1038/s42004-020-00376-z |
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