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Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions

Establishing structure–activity relationships is crucial to understand and optimize the activity of peptide-based inhibitors of protein–protein interactions. Single alanine substitutions provide limited information on the residues that tolerate simultaneous modifications with retention of biological...

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Detalles Bibliográficos
Autores principales:	Ye, Xiyun, Lee, Yen-Chun, Gates, Zachary P., Ling, Yingjie, Mortensen, Jennifer C., Yang, Fan-Shen, Lin, Yu-Shan, Pentelute, Bradley L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814900/ https://www.ncbi.nlm.nih.gov/pubmed/36697672 http://dx.doi.org/10.1038/s42004-022-00737-w

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