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Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

INTRODUCTION: Progranulin (PGRN) is a secreted glycoprotein, the expression of which is linked to several neurodegenerative diseases. Although its specific function is still unclear, several studies have linked it with lysosomal functions and immune system regulation. Here, we have explored the role...

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Detalles Bibliográficos
Autores principales:	Houser, Madelyn C., Uriarte Huarte, Oihane, Wallings, Rebecca L., Keating, Cody E., MacPherson, Kathryn P., Herrick, Mary K., Kannarkat, George T., Kelly, Sean D., Chang, Jianjun, Varvel, Nicholas H., Rexach, Jessica E., Tansey, Malú Gámez
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814971/ https://www.ncbi.nlm.nih.gov/pubmed/36618392 http://dx.doi.org/10.3389/fimmu.2022.1056417

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