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JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation

OBJECTIVES: Macrophage subsets, activated by T cells, are increasingly recognised to play a central role in rheumatoid arthritis (RA) pathogenesis. Janus kinase (JAK) inhibitors have proven beneficial clinical effects in RA. In this study, we investigated the effect of JAK inhibitors on the generati...

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Detalles Bibliográficos
Autores principales:	Nyirenda, Mukanthu H, Nijjar, Jagtar Singh, Frleta-Gilchrist, Marina, Gilchrist, Derek S, Porter, Duncan, Siebert, Stefan, Goodyear, Carl S, McInnes, Iain B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Treatments
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815080/ https://www.ncbi.nlm.nih.gov/pubmed/36599629 http://dx.doi.org/10.1136/rmdopen-2022-002671

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