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Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglut...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815151/ https://www.ncbi.nlm.nih.gov/pubmed/36618642 http://dx.doi.org/10.3389/fpls.2022.1102411 |
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author | Ai, Likun Fu, Shiqi Li, Yong Zuo, Mei Huang, Wen Huang, Jian Jin, Zhichao Chen, Yang |
author_facet | Ai, Likun Fu, Shiqi Li, Yong Zuo, Mei Huang, Wen Huang, Jian Jin, Zhichao Chen, Yang |
author_sort | Ai, Likun |
collection | PubMed |
description | Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against Pyricularia oryzae, Fusarium graminearum, Alternaria brassicae, Valsa mali, and Alternaria alternariae showed moderate antifungal activity. For instance, C08a and C08l provide potential lead agents for controlling Fusarium graminearum because of their inhibitory activity. |
format | Online Article Text |
id | pubmed-9815151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98151512023-01-06 Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues Ai, Likun Fu, Shiqi Li, Yong Zuo, Mei Huang, Wen Huang, Jian Jin, Zhichao Chen, Yang Front Plant Sci Plant Science Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against Pyricularia oryzae, Fusarium graminearum, Alternaria brassicae, Valsa mali, and Alternaria alternariae showed moderate antifungal activity. For instance, C08a and C08l provide potential lead agents for controlling Fusarium graminearum because of their inhibitory activity. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9815151/ /pubmed/36618642 http://dx.doi.org/10.3389/fpls.2022.1102411 Text en Copyright © 2022 Ai, Fu, Li, Zuo, Huang, Huang, Jin and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Ai, Likun Fu, Shiqi Li, Yong Zuo, Mei Huang, Wen Huang, Jian Jin, Zhichao Chen, Yang Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues |
title | Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues |
title_full | Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues |
title_fullStr | Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues |
title_full_unstemmed | Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues |
title_short | Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues |
title_sort | natural products-based: synthesis and antifungal activity evaluation of novel l-pyroglutamic acid analogues |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815151/ https://www.ncbi.nlm.nih.gov/pubmed/36618642 http://dx.doi.org/10.3389/fpls.2022.1102411 |
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