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Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues

Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglut...

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Autores principales: Ai, Likun, Fu, Shiqi, Li, Yong, Zuo, Mei, Huang, Wen, Huang, Jian, Jin, Zhichao, Chen, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815151/
https://www.ncbi.nlm.nih.gov/pubmed/36618642
http://dx.doi.org/10.3389/fpls.2022.1102411
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author Ai, Likun
Fu, Shiqi
Li, Yong
Zuo, Mei
Huang, Wen
Huang, Jian
Jin, Zhichao
Chen, Yang
author_facet Ai, Likun
Fu, Shiqi
Li, Yong
Zuo, Mei
Huang, Wen
Huang, Jian
Jin, Zhichao
Chen, Yang
author_sort Ai, Likun
collection PubMed
description Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against Pyricularia oryzae, Fusarium graminearum, Alternaria brassicae, Valsa mali, and Alternaria alternariae showed moderate antifungal activity. For instance, C08a and C08l provide potential lead agents for controlling Fusarium graminearum because of their inhibitory activity.
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spelling pubmed-98151512023-01-06 Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues Ai, Likun Fu, Shiqi Li, Yong Zuo, Mei Huang, Wen Huang, Jian Jin, Zhichao Chen, Yang Front Plant Sci Plant Science Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against Pyricularia oryzae, Fusarium graminearum, Alternaria brassicae, Valsa mali, and Alternaria alternariae showed moderate antifungal activity. For instance, C08a and C08l provide potential lead agents for controlling Fusarium graminearum because of their inhibitory activity. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9815151/ /pubmed/36618642 http://dx.doi.org/10.3389/fpls.2022.1102411 Text en Copyright © 2022 Ai, Fu, Li, Zuo, Huang, Huang, Jin and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Ai, Likun
Fu, Shiqi
Li, Yong
Zuo, Mei
Huang, Wen
Huang, Jian
Jin, Zhichao
Chen, Yang
Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
title Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
title_full Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
title_fullStr Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
title_full_unstemmed Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
title_short Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
title_sort natural products-based: synthesis and antifungal activity evaluation of novel l-pyroglutamic acid analogues
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815151/
https://www.ncbi.nlm.nih.gov/pubmed/36618642
http://dx.doi.org/10.3389/fpls.2022.1102411
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