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Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults

Chronic consumption of sugar- and artificially-sweetened beverages (SSB and ASB) are associated with an increased risk of stroke but it is unclear how acute consumption influences cerebral vascular function. Purpose: We hypothesized that: (1) acute consumption of SSB and ASB would augment dynamic ce...

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Autores principales: Reed, Emma L., Worley, Morgan L., Kueck, Paul J., Pietrafasa, Leonard D., Schlader, Zachary J., Johnson, Blair D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815463/
https://www.ncbi.nlm.nih.gov/pubmed/36618993
http://dx.doi.org/10.3389/fnhum.2022.1063273
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author Reed, Emma L.
Worley, Morgan L.
Kueck, Paul J.
Pietrafasa, Leonard D.
Schlader, Zachary J.
Johnson, Blair D.
author_facet Reed, Emma L.
Worley, Morgan L.
Kueck, Paul J.
Pietrafasa, Leonard D.
Schlader, Zachary J.
Johnson, Blair D.
author_sort Reed, Emma L.
collection PubMed
description Chronic consumption of sugar- and artificially-sweetened beverages (SSB and ASB) are associated with an increased risk of stroke but it is unclear how acute consumption influences cerebral vascular function. Purpose: We hypothesized that: (1) acute consumption of SSB and ASB would augment dynamic cerebral autoregulation (dCA) and attenuate cerebral vascular reactivity to hypercapnia (CVR(CO2)) compared to water; and (2) dCA and CVR(CO2) would be attenuated with SSB compared to ASB and water. Methods: Twelve healthy adults (age: 23 ± 2 years, four females) completed three randomized trials where they drank 500 ml of water, SSB (Mountain Dew(®)), or ASB (Diet Mountain Dew(®)). We measured mean arterial pressure (MAP), middle and posterior cerebral artery blood velocities (MCAv and PCAv), and end-tidal CO(2) tension (PETCO(2)). Cerebral vascular conductance was calculated as cerebral artery blood velocity/MAP (MCAc and PCAc). Twenty min after consumption, participants completed a 5 min baseline, and in a counterbalanced order, a CVR(CO2) test (3%, 5%, and 7% CO(2) in 3 min stages) and a dCA test (squat-stand tests at 0.10 Hz and 0.05 Hz for 5 min each) separated by 10 min. CVR(CO2) was calculated as the slope of the linear regression lines of MCAv and PCAv vs. PETCO(2). dCA was assessed in the MCA using transfer function analysis. Coherence, gain, and phase were determined in the low frequency (LF; 0.07–0.2 Hz) and very low frequency (VLF; 0.02–0.07 Hz). Results: MCAv and MCAc were lower after SSB (54.11 ± 12.28 cm/s, 0.58 ± 0.15 cm/s/mmHg) and ASB (51.07 ± 9.35 cm/s, 0.52 ± 1.0 cm/s/mmHg) vs. water (62.73 ± 12.96 cm/s, 0.67 ± 0.11 cm/s/mmHg; all P < 0.035), respectively. PCAc was also lower with the ASB compared to water (P = 0.007). MCA CVR(CO2) was lower following ASB (1.55 ± 0.38 cm/s/mmHg) vs. water (2.00 ± 0.57 cm/s/mmHg; P = 0.011) but not after SSB (1.90 ± 0.67 cm/s/mmHg; P = 0.593). PCA CVR(CO2) did not differ between beverages (P > 0.853). There were no differences between beverages for coherence (P ≥ 0.295), gain (P ≥ 0.058), or phase (P ≥ 0.084) for either frequency. Discussion: Acute consumption of caffeinated SSB and ASB resulted in lower intracranial artery blood velocity and conductance but had a minimal effect on cerebral vascular function as only MCA CVR(CO2) was altered with the ASB compared to water.
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spelling pubmed-98154632023-01-06 Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults Reed, Emma L. Worley, Morgan L. Kueck, Paul J. Pietrafasa, Leonard D. Schlader, Zachary J. Johnson, Blair D. Front Hum Neurosci Human Neuroscience Chronic consumption of sugar- and artificially-sweetened beverages (SSB and ASB) are associated with an increased risk of stroke but it is unclear how acute consumption influences cerebral vascular function. Purpose: We hypothesized that: (1) acute consumption of SSB and ASB would augment dynamic cerebral autoregulation (dCA) and attenuate cerebral vascular reactivity to hypercapnia (CVR(CO2)) compared to water; and (2) dCA and CVR(CO2) would be attenuated with SSB compared to ASB and water. Methods: Twelve healthy adults (age: 23 ± 2 years, four females) completed three randomized trials where they drank 500 ml of water, SSB (Mountain Dew(®)), or ASB (Diet Mountain Dew(®)). We measured mean arterial pressure (MAP), middle and posterior cerebral artery blood velocities (MCAv and PCAv), and end-tidal CO(2) tension (PETCO(2)). Cerebral vascular conductance was calculated as cerebral artery blood velocity/MAP (MCAc and PCAc). Twenty min after consumption, participants completed a 5 min baseline, and in a counterbalanced order, a CVR(CO2) test (3%, 5%, and 7% CO(2) in 3 min stages) and a dCA test (squat-stand tests at 0.10 Hz and 0.05 Hz for 5 min each) separated by 10 min. CVR(CO2) was calculated as the slope of the linear regression lines of MCAv and PCAv vs. PETCO(2). dCA was assessed in the MCA using transfer function analysis. Coherence, gain, and phase were determined in the low frequency (LF; 0.07–0.2 Hz) and very low frequency (VLF; 0.02–0.07 Hz). Results: MCAv and MCAc were lower after SSB (54.11 ± 12.28 cm/s, 0.58 ± 0.15 cm/s/mmHg) and ASB (51.07 ± 9.35 cm/s, 0.52 ± 1.0 cm/s/mmHg) vs. water (62.73 ± 12.96 cm/s, 0.67 ± 0.11 cm/s/mmHg; all P < 0.035), respectively. PCAc was also lower with the ASB compared to water (P = 0.007). MCA CVR(CO2) was lower following ASB (1.55 ± 0.38 cm/s/mmHg) vs. water (2.00 ± 0.57 cm/s/mmHg; P = 0.011) but not after SSB (1.90 ± 0.67 cm/s/mmHg; P = 0.593). PCA CVR(CO2) did not differ between beverages (P > 0.853). There were no differences between beverages for coherence (P ≥ 0.295), gain (P ≥ 0.058), or phase (P ≥ 0.084) for either frequency. Discussion: Acute consumption of caffeinated SSB and ASB resulted in lower intracranial artery blood velocity and conductance but had a minimal effect on cerebral vascular function as only MCA CVR(CO2) was altered with the ASB compared to water. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9815463/ /pubmed/36618993 http://dx.doi.org/10.3389/fnhum.2022.1063273 Text en Copyright © 2022 Reed, Worley, Kueck, Pietrafasa, Schlader and Johnson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Reed, Emma L.
Worley, Morgan L.
Kueck, Paul J.
Pietrafasa, Leonard D.
Schlader, Zachary J.
Johnson, Blair D.
Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults
title Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults
title_full Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults
title_fullStr Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults
title_full_unstemmed Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults
title_short Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults
title_sort cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815463/
https://www.ncbi.nlm.nih.gov/pubmed/36618993
http://dx.doi.org/10.3389/fnhum.2022.1063273
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