High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells

Tumor-infiltrating immune cells experience significant metabolic reprogramming in the tumor microenvironment (TME), and they share similar metabolic pathways and nutrient needs with malignant cells. This positions these cell types in direct nutrient competition in the TME. We currently lack a comple...

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Detalles Bibliográficos
Autores principales: Valvo, Veronica, Parietti, Elena, Deans, Kyle, Ahn, Sebastian W., Park, Noel Ruth, Ferland, Benjamin, Thompson, Devon, Dominas, Christine, Bhagavatula, Sharath K., Davidson, Shawn, Jonas, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815512/
https://www.ncbi.nlm.nih.gov/pubmed/36619865
http://dx.doi.org/10.3389/fcell.2022.1032360

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