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Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders
The occurrence and progression of colorectal cancer (CRC) are closely related to intestinal microecological disorders. Butyrate, the representative of short chain fatty acids, possess anti-inflammatory and antioxidant effects, and its antitumor effect has been gradually paid attention to. In this st...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815807/ https://www.ncbi.nlm.nih.gov/pubmed/36305358 http://dx.doi.org/10.1097/CAD.0000000000001413 |
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author | Kang, Jingjing Sun, Mingzhong Chang, Yi Chen, Hongmei Zhang, Juan Liang, Xiaodong Xiao, Tengfei |
author_facet | Kang, Jingjing Sun, Mingzhong Chang, Yi Chen, Hongmei Zhang, Juan Liang, Xiaodong Xiao, Tengfei |
author_sort | Kang, Jingjing |
collection | PubMed |
description | The occurrence and progression of colorectal cancer (CRC) are closely related to intestinal microecological disorders. Butyrate, the representative of short chain fatty acids, possess anti-inflammatory and antioxidant effects, and its antitumor effect has been gradually paid attention to. In this study, azoxymethane/dextran sodium sulfate induced mouse CRC model was used to explore the role and mechanism of butyrate in regulating colon cancer and its intestinal microecological balance. Outcomes exhibited that butyrate alleviated weight loss, disease activity index, and survival in CRC mice and inhibited tumor number and progression. Further research revealed that butyrate restrained the aggregation of harmful while promoting the colonization of beneficial flora, such as Actinobacteriota, Bifidobacteriales and Muribaculacea through 16S rDNA sequence analysis. This study confirmed that butyrate can ameliorate CRC by repairing intestinal microecology, providing ideas and evidence for chemical prophylactic agents, such as butyrate to remedy tumors and regulate tumor microbiota. |
format | Online Article Text |
id | pubmed-9815807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-98158072023-01-31 Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders Kang, Jingjing Sun, Mingzhong Chang, Yi Chen, Hongmei Zhang, Juan Liang, Xiaodong Xiao, Tengfei Anticancer Drugs Preclinical Reports The occurrence and progression of colorectal cancer (CRC) are closely related to intestinal microecological disorders. Butyrate, the representative of short chain fatty acids, possess anti-inflammatory and antioxidant effects, and its antitumor effect has been gradually paid attention to. In this study, azoxymethane/dextran sodium sulfate induced mouse CRC model was used to explore the role and mechanism of butyrate in regulating colon cancer and its intestinal microecological balance. Outcomes exhibited that butyrate alleviated weight loss, disease activity index, and survival in CRC mice and inhibited tumor number and progression. Further research revealed that butyrate restrained the aggregation of harmful while promoting the colonization of beneficial flora, such as Actinobacteriota, Bifidobacteriales and Muribaculacea through 16S rDNA sequence analysis. This study confirmed that butyrate can ameliorate CRC by repairing intestinal microecology, providing ideas and evidence for chemical prophylactic agents, such as butyrate to remedy tumors and regulate tumor microbiota. Lippincott Williams & Wilkins 2022-10-24 2023-02 /pmc/articles/PMC9815807/ /pubmed/36305358 http://dx.doi.org/10.1097/CAD.0000000000001413 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Preclinical Reports Kang, Jingjing Sun, Mingzhong Chang, Yi Chen, Hongmei Zhang, Juan Liang, Xiaodong Xiao, Tengfei Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders |
title | Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders |
title_full | Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders |
title_fullStr | Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders |
title_full_unstemmed | Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders |
title_short | Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders |
title_sort | butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders |
topic | Preclinical Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815807/ https://www.ncbi.nlm.nih.gov/pubmed/36305358 http://dx.doi.org/10.1097/CAD.0000000000001413 |
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