Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice

Axin1 is a key regulator of canonical Wnt signaling pathway. Roles of Axin1 in skeletal development and in disease occurrence have not been fully defined. Here, we report that Axin1 is essential for lower limb development. Specific deletion of Axin1 in limb mesenchymal cells leads to fibular hemimel...

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Detalles Bibliográficos
Autores principales: Xie, Rong, Yi, Dan, Zeng, Daofu, Jie, Qiang, Kang, Qinglin, Zhang, Zeng, Zhang, Zhenlin, Xiao, Guozhi, Chen, Lin, Tong, Liping, Chen, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815809/
https://www.ncbi.nlm.nih.gov/pubmed/36541713
http://dx.doi.org/10.7554/eLife.80013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815809/
https://www.ncbi.nlm.nih.gov/pubmed/36541713
http://dx.doi.org/10.7554/eLife.80013

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