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Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review
Nailfold video-capillaroscopy (NVC) is an inexpensive method of assessing microcirculation. We reviewed the literature to assess whether changes to the nailfold capillaries exist in patients with cardiovascular disease (CVD). METHODS: We searched PubMed, Scopus and Cochrane Library databases for ori...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815820/ https://www.ncbi.nlm.nih.gov/pubmed/36281701 http://dx.doi.org/10.1097/MBP.0000000000000624 |
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author | Lim, Matthew W.S. Setjiadi, Dellaneira Dobbin, Stephen J.H. Lang, Ninian N. Delles, Christian Connelly, Paul J. |
author_facet | Lim, Matthew W.S. Setjiadi, Dellaneira Dobbin, Stephen J.H. Lang, Ninian N. Delles, Christian Connelly, Paul J. |
author_sort | Lim, Matthew W.S. |
collection | PubMed |
description | Nailfold video-capillaroscopy (NVC) is an inexpensive method of assessing microcirculation. We reviewed the literature to assess whether changes to the nailfold capillaries exist in patients with cardiovascular disease (CVD). METHODS: We searched PubMed, Scopus and Cochrane Library databases for original research articles relating to the use of noninvasive microvascular assessment in patients with CVD. Methodological quality was assessed with the ‘Quality Assessment Tool for Observational Cohort and Cross-sectional Studies.’ The results obtained from NVC were analysed qualitatively and compared with other forms of microvascular assessment. RESULTS: In total 2759 articles were screened, of which 22 studies involving 562 patients (~40% women) with CVD were included. Mean age ranged between 3.7–68.4 years (cases) and 4.0–58.0 years (controls). Reduced capillary density and increased capillary dimensions were seen in patients with pulmonary arterial hypertension (PAH). Among patients with systemic sclerosis, advanced scleroderma patterns can be used to identify patients with or at risk of developing PAH. Functional nailfold changes precede structural changes in patients with hypertension. However, the studies were heterogeneous in the diagnosis of disease and the measurement of nailfold parameters. Most studies did not exclude conditions with altered nailfold features, and only one study performed a power calculation. Furthermore, abnormal nailfold findings are present in patients without systemic disease. CONCLUSIONS: Structural and functional changes to the nailfold are a feature of established CVD and precede the development of PAH. However, heterogeneity in measurement and abnormal findings in healthy participants limit their use in the wider population. |
format | Online Article Text |
id | pubmed-9815820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-98158202023-01-12 Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review Lim, Matthew W.S. Setjiadi, Dellaneira Dobbin, Stephen J.H. Lang, Ninian N. Delles, Christian Connelly, Paul J. Blood Press Monit Clinical Methods and Pathophysiology Nailfold video-capillaroscopy (NVC) is an inexpensive method of assessing microcirculation. We reviewed the literature to assess whether changes to the nailfold capillaries exist in patients with cardiovascular disease (CVD). METHODS: We searched PubMed, Scopus and Cochrane Library databases for original research articles relating to the use of noninvasive microvascular assessment in patients with CVD. Methodological quality was assessed with the ‘Quality Assessment Tool for Observational Cohort and Cross-sectional Studies.’ The results obtained from NVC were analysed qualitatively and compared with other forms of microvascular assessment. RESULTS: In total 2759 articles were screened, of which 22 studies involving 562 patients (~40% women) with CVD were included. Mean age ranged between 3.7–68.4 years (cases) and 4.0–58.0 years (controls). Reduced capillary density and increased capillary dimensions were seen in patients with pulmonary arterial hypertension (PAH). Among patients with systemic sclerosis, advanced scleroderma patterns can be used to identify patients with or at risk of developing PAH. Functional nailfold changes precede structural changes in patients with hypertension. However, the studies were heterogeneous in the diagnosis of disease and the measurement of nailfold parameters. Most studies did not exclude conditions with altered nailfold features, and only one study performed a power calculation. Furthermore, abnormal nailfold findings are present in patients without systemic disease. CONCLUSIONS: Structural and functional changes to the nailfold are a feature of established CVD and precede the development of PAH. However, heterogeneity in measurement and abnormal findings in healthy participants limit their use in the wider population. Lippincott Williams & Wilkins 2022-10-20 2023-02 /pmc/articles/PMC9815820/ /pubmed/36281701 http://dx.doi.org/10.1097/MBP.0000000000000624 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Methods and Pathophysiology Lim, Matthew W.S. Setjiadi, Dellaneira Dobbin, Stephen J.H. Lang, Ninian N. Delles, Christian Connelly, Paul J. Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review |
title | Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review |
title_full | Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review |
title_fullStr | Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review |
title_full_unstemmed | Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review |
title_short | Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review |
title_sort | nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review |
topic | Clinical Methods and Pathophysiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815820/ https://www.ncbi.nlm.nih.gov/pubmed/36281701 http://dx.doi.org/10.1097/MBP.0000000000000624 |
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