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Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

Stellate ganglia within the intrathoracic cardiac control system receive and integrate central, peripheral, and cardiopulmonary information to produce postganglionic cardiac sympathetic inputs. Pathological anatomical and structural remodeling occurs within the neurons of the stellate ganglion (SG)...

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Autores principales: Gurel, Nil Z, Sudarshan, Koustubh B, Hadaya, Joseph, Karavos, Alex, Temma, Taro, Hori, Yuichi, Armour, J Andrew, Kember, Guy, Ajijola, Olujimi A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815826/
https://www.ncbi.nlm.nih.gov/pubmed/36426848
http://dx.doi.org/10.7554/eLife.78520
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author Gurel, Nil Z
Sudarshan, Koustubh B
Hadaya, Joseph
Karavos, Alex
Temma, Taro
Hori, Yuichi
Armour, J Andrew
Kember, Guy
Ajijola, Olujimi A
author_facet Gurel, Nil Z
Sudarshan, Koustubh B
Hadaya, Joseph
Karavos, Alex
Temma, Taro
Hori, Yuichi
Armour, J Andrew
Kember, Guy
Ajijola, Olujimi A
author_sort Gurel, Nil Z
collection PubMed
description Stellate ganglia within the intrathoracic cardiac control system receive and integrate central, peripheral, and cardiopulmonary information to produce postganglionic cardiac sympathetic inputs. Pathological anatomical and structural remodeling occurs within the neurons of the stellate ganglion (SG) in the setting of heart failure (HF). A large proportion of SG neurons function as interneurons whose networking capabilities are largely unknown. Current therapies are limited to targeting sympathetic activity at the cardiac level or surgical interventions such as stellectomy, to treat HF. Future therapies that target the SG will require understanding of their networking capabilities to modify any pathological remodeling. We observe SG networking by examining cofluctuation and specificity of SG networked activity to cardiac cycle phases. We investigate network processing of cardiopulmonary transduction by SG neuronal populations in porcine with chronic pacing-induced HF and control subjects during extended in-vivo extracellular microelectrode recordings. We find that information processing and cardiac control in chronic HF by the SG, relative to controls, exhibits: (i) more frequent, short-lived, high magnitude cofluctuations, (ii) greater variation in neural specificity to cardiac cycles, and (iii) neural network activity and cardiac control linkage that depends on disease state and cofluctuation magnitude.
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spelling pubmed-98158262023-01-06 Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion Gurel, Nil Z Sudarshan, Koustubh B Hadaya, Joseph Karavos, Alex Temma, Taro Hori, Yuichi Armour, J Andrew Kember, Guy Ajijola, Olujimi A eLife Computational and Systems Biology Stellate ganglia within the intrathoracic cardiac control system receive and integrate central, peripheral, and cardiopulmonary information to produce postganglionic cardiac sympathetic inputs. Pathological anatomical and structural remodeling occurs within the neurons of the stellate ganglion (SG) in the setting of heart failure (HF). A large proportion of SG neurons function as interneurons whose networking capabilities are largely unknown. Current therapies are limited to targeting sympathetic activity at the cardiac level or surgical interventions such as stellectomy, to treat HF. Future therapies that target the SG will require understanding of their networking capabilities to modify any pathological remodeling. We observe SG networking by examining cofluctuation and specificity of SG networked activity to cardiac cycle phases. We investigate network processing of cardiopulmonary transduction by SG neuronal populations in porcine with chronic pacing-induced HF and control subjects during extended in-vivo extracellular microelectrode recordings. We find that information processing and cardiac control in chronic HF by the SG, relative to controls, exhibits: (i) more frequent, short-lived, high magnitude cofluctuations, (ii) greater variation in neural specificity to cardiac cycles, and (iii) neural network activity and cardiac control linkage that depends on disease state and cofluctuation magnitude. eLife Sciences Publications, Ltd 2022-11-25 /pmc/articles/PMC9815826/ /pubmed/36426848 http://dx.doi.org/10.7554/eLife.78520 Text en © 2022, Gurel, Sudarshan et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Gurel, Nil Z
Sudarshan, Koustubh B
Hadaya, Joseph
Karavos, Alex
Temma, Taro
Hori, Yuichi
Armour, J Andrew
Kember, Guy
Ajijola, Olujimi A
Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion
title Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion
title_full Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion
title_fullStr Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion
title_full_unstemmed Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion
title_short Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion
title_sort metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815826/
https://www.ncbi.nlm.nih.gov/pubmed/36426848
http://dx.doi.org/10.7554/eLife.78520
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