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The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention

METHODS: Between 2015 and 2018, 580 men undergoing PCI at a tertiary referral hospital were divided into low (<3.25 ng/mL) and normal (≥3.25 ng/mL) testosterone groups. Major adverse cardiovascular event (MACE) was defined as the composite outcome of CV death, myocardial infarction, and target le...

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Autores principales: Chiang, Cheng-Hung, Hung, Wan-Ting, Liu, En-Shao, Yang, Tse-Hsuan, Cheng, Chin-Chang, Huang, Wei-Chun, Mar, Guang-Yuan, Kuo, Feng-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815835/
https://www.ncbi.nlm.nih.gov/pubmed/36620620
http://dx.doi.org/10.3389/fcvm.2022.998056
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author Chiang, Cheng-Hung
Hung, Wan-Ting
Liu, En-Shao
Yang, Tse-Hsuan
Cheng, Chin-Chang
Huang, Wei-Chun
Mar, Guang-Yuan
Kuo, Feng-Yu
author_facet Chiang, Cheng-Hung
Hung, Wan-Ting
Liu, En-Shao
Yang, Tse-Hsuan
Cheng, Chin-Chang
Huang, Wei-Chun
Mar, Guang-Yuan
Kuo, Feng-Yu
author_sort Chiang, Cheng-Hung
collection PubMed
description METHODS: Between 2015 and 2018, 580 men undergoing PCI at a tertiary referral hospital were divided into low (<3.25 ng/mL) and normal (≥3.25 ng/mL) testosterone groups. Major adverse cardiovascular event (MACE) was defined as the composite outcome of CV death, myocardial infarction, and target lesion revascularization/target vessel revascularization (TLR/TVR) during up to 48 months follow-up after PCI. RESULTS: There were 111 and 469 patients in the low and normal testosterone groups, respectively, with the overall MACE rate of the former being higher than the latter (26.13% vs. 13.01%, p = 0.0006). Moreover, the overall TLR/TVR (20.72% vs. 11.73%, p = 0.0125) and myocardial infarction (3.6% vs. 0.85%, p = 0.0255) rates were significantly higher in those with low serum testosterone who also had a shorter average event-free survival analysis of MACE (25.22 ± 0.88 months) than those with normal testosterone levels (35.09 ± 0.47 months, log-rank p = 0.0004). Multiple logistic regression demonstrated an association between low serum testosterone (<3.25 ng/mL) and a higher MACE rate [odds ratio: 2.06, 95% confidence interval (CI) 1.21–3.51, p = 0.0081]. After adjusting for variables in a Cox regression model, hazard ratios (HRs) for MACE (HR: 1.88, 95% CI: 1.20–2.95, p = 0.0058) and TLR/TVR (HR: 1.73, 95% CI: 1.06–2.83, p = 0.0290) rates were higher in the low testosterone group than those in the normal testosterone group. CONCLUSION: Low serum testosterone concentrations were associated with a higher risk of MACE and TLR/TVR after PCI than those with normal testosterone levels.
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spelling pubmed-98158352023-01-06 The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention Chiang, Cheng-Hung Hung, Wan-Ting Liu, En-Shao Yang, Tse-Hsuan Cheng, Chin-Chang Huang, Wei-Chun Mar, Guang-Yuan Kuo, Feng-Yu Front Cardiovasc Med Cardiovascular Medicine METHODS: Between 2015 and 2018, 580 men undergoing PCI at a tertiary referral hospital were divided into low (<3.25 ng/mL) and normal (≥3.25 ng/mL) testosterone groups. Major adverse cardiovascular event (MACE) was defined as the composite outcome of CV death, myocardial infarction, and target lesion revascularization/target vessel revascularization (TLR/TVR) during up to 48 months follow-up after PCI. RESULTS: There were 111 and 469 patients in the low and normal testosterone groups, respectively, with the overall MACE rate of the former being higher than the latter (26.13% vs. 13.01%, p = 0.0006). Moreover, the overall TLR/TVR (20.72% vs. 11.73%, p = 0.0125) and myocardial infarction (3.6% vs. 0.85%, p = 0.0255) rates were significantly higher in those with low serum testosterone who also had a shorter average event-free survival analysis of MACE (25.22 ± 0.88 months) than those with normal testosterone levels (35.09 ± 0.47 months, log-rank p = 0.0004). Multiple logistic regression demonstrated an association between low serum testosterone (<3.25 ng/mL) and a higher MACE rate [odds ratio: 2.06, 95% confidence interval (CI) 1.21–3.51, p = 0.0081]. After adjusting for variables in a Cox regression model, hazard ratios (HRs) for MACE (HR: 1.88, 95% CI: 1.20–2.95, p = 0.0058) and TLR/TVR (HR: 1.73, 95% CI: 1.06–2.83, p = 0.0290) rates were higher in the low testosterone group than those in the normal testosterone group. CONCLUSION: Low serum testosterone concentrations were associated with a higher risk of MACE and TLR/TVR after PCI than those with normal testosterone levels. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9815835/ /pubmed/36620620 http://dx.doi.org/10.3389/fcvm.2022.998056 Text en Copyright © 2022 Chiang, Hung, Liu, Yang, Cheng, Huang, Mar and Kuo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Chiang, Cheng-Hung
Hung, Wan-Ting
Liu, En-Shao
Yang, Tse-Hsuan
Cheng, Chin-Chang
Huang, Wei-Chun
Mar, Guang-Yuan
Kuo, Feng-Yu
The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
title The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
title_full The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
title_fullStr The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
title_full_unstemmed The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
title_short The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
title_sort influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815835/
https://www.ncbi.nlm.nih.gov/pubmed/36620620
http://dx.doi.org/10.3389/fcvm.2022.998056
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