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The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention
METHODS: Between 2015 and 2018, 580 men undergoing PCI at a tertiary referral hospital were divided into low (<3.25 ng/mL) and normal (≥3.25 ng/mL) testosterone groups. Major adverse cardiovascular event (MACE) was defined as the composite outcome of CV death, myocardial infarction, and target le...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815835/ https://www.ncbi.nlm.nih.gov/pubmed/36620620 http://dx.doi.org/10.3389/fcvm.2022.998056 |
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author | Chiang, Cheng-Hung Hung, Wan-Ting Liu, En-Shao Yang, Tse-Hsuan Cheng, Chin-Chang Huang, Wei-Chun Mar, Guang-Yuan Kuo, Feng-Yu |
author_facet | Chiang, Cheng-Hung Hung, Wan-Ting Liu, En-Shao Yang, Tse-Hsuan Cheng, Chin-Chang Huang, Wei-Chun Mar, Guang-Yuan Kuo, Feng-Yu |
author_sort | Chiang, Cheng-Hung |
collection | PubMed |
description | METHODS: Between 2015 and 2018, 580 men undergoing PCI at a tertiary referral hospital were divided into low (<3.25 ng/mL) and normal (≥3.25 ng/mL) testosterone groups. Major adverse cardiovascular event (MACE) was defined as the composite outcome of CV death, myocardial infarction, and target lesion revascularization/target vessel revascularization (TLR/TVR) during up to 48 months follow-up after PCI. RESULTS: There were 111 and 469 patients in the low and normal testosterone groups, respectively, with the overall MACE rate of the former being higher than the latter (26.13% vs. 13.01%, p = 0.0006). Moreover, the overall TLR/TVR (20.72% vs. 11.73%, p = 0.0125) and myocardial infarction (3.6% vs. 0.85%, p = 0.0255) rates were significantly higher in those with low serum testosterone who also had a shorter average event-free survival analysis of MACE (25.22 ± 0.88 months) than those with normal testosterone levels (35.09 ± 0.47 months, log-rank p = 0.0004). Multiple logistic regression demonstrated an association between low serum testosterone (<3.25 ng/mL) and a higher MACE rate [odds ratio: 2.06, 95% confidence interval (CI) 1.21–3.51, p = 0.0081]. After adjusting for variables in a Cox regression model, hazard ratios (HRs) for MACE (HR: 1.88, 95% CI: 1.20–2.95, p = 0.0058) and TLR/TVR (HR: 1.73, 95% CI: 1.06–2.83, p = 0.0290) rates were higher in the low testosterone group than those in the normal testosterone group. CONCLUSION: Low serum testosterone concentrations were associated with a higher risk of MACE and TLR/TVR after PCI than those with normal testosterone levels. |
format | Online Article Text |
id | pubmed-9815835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98158352023-01-06 The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention Chiang, Cheng-Hung Hung, Wan-Ting Liu, En-Shao Yang, Tse-Hsuan Cheng, Chin-Chang Huang, Wei-Chun Mar, Guang-Yuan Kuo, Feng-Yu Front Cardiovasc Med Cardiovascular Medicine METHODS: Between 2015 and 2018, 580 men undergoing PCI at a tertiary referral hospital were divided into low (<3.25 ng/mL) and normal (≥3.25 ng/mL) testosterone groups. Major adverse cardiovascular event (MACE) was defined as the composite outcome of CV death, myocardial infarction, and target lesion revascularization/target vessel revascularization (TLR/TVR) during up to 48 months follow-up after PCI. RESULTS: There were 111 and 469 patients in the low and normal testosterone groups, respectively, with the overall MACE rate of the former being higher than the latter (26.13% vs. 13.01%, p = 0.0006). Moreover, the overall TLR/TVR (20.72% vs. 11.73%, p = 0.0125) and myocardial infarction (3.6% vs. 0.85%, p = 0.0255) rates were significantly higher in those with low serum testosterone who also had a shorter average event-free survival analysis of MACE (25.22 ± 0.88 months) than those with normal testosterone levels (35.09 ± 0.47 months, log-rank p = 0.0004). Multiple logistic regression demonstrated an association between low serum testosterone (<3.25 ng/mL) and a higher MACE rate [odds ratio: 2.06, 95% confidence interval (CI) 1.21–3.51, p = 0.0081]. After adjusting for variables in a Cox regression model, hazard ratios (HRs) for MACE (HR: 1.88, 95% CI: 1.20–2.95, p = 0.0058) and TLR/TVR (HR: 1.73, 95% CI: 1.06–2.83, p = 0.0290) rates were higher in the low testosterone group than those in the normal testosterone group. CONCLUSION: Low serum testosterone concentrations were associated with a higher risk of MACE and TLR/TVR after PCI than those with normal testosterone levels. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9815835/ /pubmed/36620620 http://dx.doi.org/10.3389/fcvm.2022.998056 Text en Copyright © 2022 Chiang, Hung, Liu, Yang, Cheng, Huang, Mar and Kuo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Chiang, Cheng-Hung Hung, Wan-Ting Liu, En-Shao Yang, Tse-Hsuan Cheng, Chin-Chang Huang, Wei-Chun Mar, Guang-Yuan Kuo, Feng-Yu The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention |
title | The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention |
title_full | The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention |
title_fullStr | The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention |
title_full_unstemmed | The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention |
title_short | The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention |
title_sort | influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815835/ https://www.ncbi.nlm.nih.gov/pubmed/36620620 http://dx.doi.org/10.3389/fcvm.2022.998056 |
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