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Pre-existing conditions associated with post-acute sequelae of COVID-19

Post-acute sequelae of COVID-19 (PASC) are conditions that occur or remain at least 28 days after SARS-CoV-2 infection. While some risk factors for PASC have been identified, little is known about pre-existing conditions that render one susceptible to developing PASC. Data from participants (n = 122...

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Autores principales: Jacobs, Elizabeth T., Catalfamo, Collin J., Colombo, Paulina M., Khan, Sana M., Austhof, Erika, Cordova-Marks, Felina, Ernst, Kacey C., Farland, Leslie V., Pogreba-Brown, Kristen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816074/
https://www.ncbi.nlm.nih.gov/pubmed/36634460
http://dx.doi.org/10.1016/j.jaut.2022.102991
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author Jacobs, Elizabeth T.
Catalfamo, Collin J.
Colombo, Paulina M.
Khan, Sana M.
Austhof, Erika
Cordova-Marks, Felina
Ernst, Kacey C.
Farland, Leslie V.
Pogreba-Brown, Kristen
author_facet Jacobs, Elizabeth T.
Catalfamo, Collin J.
Colombo, Paulina M.
Khan, Sana M.
Austhof, Erika
Cordova-Marks, Felina
Ernst, Kacey C.
Farland, Leslie V.
Pogreba-Brown, Kristen
author_sort Jacobs, Elizabeth T.
collection PubMed
description Post-acute sequelae of COVID-19 (PASC) are conditions that occur or remain at least 28 days after SARS-CoV-2 infection. While some risk factors for PASC have been identified, little is known about pre-existing conditions that render one susceptible to developing PASC. Data from participants (n = 1224) in a longitudinal COVID-19 cohort study in Arizona were used to investigate comorbid conditions associated with PASC. After adjustment of the models for age, BMI, gender, race, and smoking, the following pre-existing conditions were statistically significantly associated with the development of PASC: asthma (OR = 1.54; 95% CI = 1.10–2.15); chronic constipation (OR = 4.29; 95% CI = 1.15–16.00); reflux (OR = 1.54; 95% CI = 1.01–2.34); rheumatoid arthritis (OR = 3.69; 95%CI = 1.15–11.82); seasonal allergies (OR = 1.56; 95% CI = 1.22–1.98); and depression/anxiety (OR = 1.72; 95% CI = 1.17–2.52). When grouping conditions together, statistically significant associations with PASC were observed for respiratory (OR = 1.47; 95% CI = 1.06–2.14); gastrointestinal (OR = 1.62; 95% CI = 1.16–2.26), and autoimmune conditions (OR = 4.38; 95% CI = 1.59–12.06). After adjustment for severity of acute SARS-CoV-2 infection and depression/anxiety, seasonal allergies (OR = 1.48; 95% CI 1.15–1.91) and autoimmune disease (OR = 3.78; 95% CI - 1.31-10.91) remained significantly associated with risk for PASC. These findings indicate that numerous pre-existing conditions may be associated with an increased risk for the development of PASC. Patients with these conditions should consider taking extra steps to avoid infection.
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spelling pubmed-98160742023-01-06 Pre-existing conditions associated with post-acute sequelae of COVID-19 Jacobs, Elizabeth T. Catalfamo, Collin J. Colombo, Paulina M. Khan, Sana M. Austhof, Erika Cordova-Marks, Felina Ernst, Kacey C. Farland, Leslie V. Pogreba-Brown, Kristen J Autoimmun Article Post-acute sequelae of COVID-19 (PASC) are conditions that occur or remain at least 28 days after SARS-CoV-2 infection. While some risk factors for PASC have been identified, little is known about pre-existing conditions that render one susceptible to developing PASC. Data from participants (n = 1224) in a longitudinal COVID-19 cohort study in Arizona were used to investigate comorbid conditions associated with PASC. After adjustment of the models for age, BMI, gender, race, and smoking, the following pre-existing conditions were statistically significantly associated with the development of PASC: asthma (OR = 1.54; 95% CI = 1.10–2.15); chronic constipation (OR = 4.29; 95% CI = 1.15–16.00); reflux (OR = 1.54; 95% CI = 1.01–2.34); rheumatoid arthritis (OR = 3.69; 95%CI = 1.15–11.82); seasonal allergies (OR = 1.56; 95% CI = 1.22–1.98); and depression/anxiety (OR = 1.72; 95% CI = 1.17–2.52). When grouping conditions together, statistically significant associations with PASC were observed for respiratory (OR = 1.47; 95% CI = 1.06–2.14); gastrointestinal (OR = 1.62; 95% CI = 1.16–2.26), and autoimmune conditions (OR = 4.38; 95% CI = 1.59–12.06). After adjustment for severity of acute SARS-CoV-2 infection and depression/anxiety, seasonal allergies (OR = 1.48; 95% CI 1.15–1.91) and autoimmune disease (OR = 3.78; 95% CI - 1.31-10.91) remained significantly associated with risk for PASC. These findings indicate that numerous pre-existing conditions may be associated with an increased risk for the development of PASC. Patients with these conditions should consider taking extra steps to avoid infection. Elsevier Ltd. 2023-02 2023-01-06 /pmc/articles/PMC9816074/ /pubmed/36634460 http://dx.doi.org/10.1016/j.jaut.2022.102991 Text en © 2023 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jacobs, Elizabeth T.
Catalfamo, Collin J.
Colombo, Paulina M.
Khan, Sana M.
Austhof, Erika
Cordova-Marks, Felina
Ernst, Kacey C.
Farland, Leslie V.
Pogreba-Brown, Kristen
Pre-existing conditions associated with post-acute sequelae of COVID-19
title Pre-existing conditions associated with post-acute sequelae of COVID-19
title_full Pre-existing conditions associated with post-acute sequelae of COVID-19
title_fullStr Pre-existing conditions associated with post-acute sequelae of COVID-19
title_full_unstemmed Pre-existing conditions associated with post-acute sequelae of COVID-19
title_short Pre-existing conditions associated with post-acute sequelae of COVID-19
title_sort pre-existing conditions associated with post-acute sequelae of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816074/
https://www.ncbi.nlm.nih.gov/pubmed/36634460
http://dx.doi.org/10.1016/j.jaut.2022.102991
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