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Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism
INTRODUCTION: Hypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic ske...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816127/ https://www.ncbi.nlm.nih.gov/pubmed/36619538 http://dx.doi.org/10.3389/fendo.2022.948435 |
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author | d’Alva, Catarina Brasil Barreto, André Rodrigues Façanha Nogueira-Barbosa, Marcello H. Arruda, Caio César Cavalcante Albuquerque, Áurea Maíla Praciano, Débora Mota Cordeiro Viana, Rodrigo Ponte Gadelha, Daniel Duarte Viana Jr, Antônio Brazil Moreira, Ilana Marques de Moura Filho, Francisco José Rodrigues Junqueira, Ana Flávia Torquato de Araújo Montenegro Jr, Renan Magalhães |
author_facet | d’Alva, Catarina Brasil Barreto, André Rodrigues Façanha Nogueira-Barbosa, Marcello H. Arruda, Caio César Cavalcante Albuquerque, Áurea Maíla Praciano, Débora Mota Cordeiro Viana, Rodrigo Ponte Gadelha, Daniel Duarte Viana Jr, Antônio Brazil Moreira, Ilana Marques de Moura Filho, Francisco José Rodrigues Junqueira, Ana Flávia Torquato de Araújo Montenegro Jr, Renan Magalhães |
author_sort | d’Alva, Catarina Brasil |
collection | PubMed |
description | INTRODUCTION: Hypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic skeletal changes have a negative impact on the fracture risk, it is not known. METHODS: Aiming to investigate the risk of insufficiency vertebral fractures in HP, defined using morphometric criteria, a consecutive sampling of 44 women with chronic postsurgical HP was compared to a control group of 44 adult healthy women, matched by age with patients. Vertebral fractures were analyzed by the semiquantitative Genant’s method followed by quantitative vertebral morphometry. RESULTS: Morphometric vertebral fractures were identified in 5/44 (11.4%) patients and in 3/44 (6.8%) controls (p=0.731). Most fractures were classified as Genant II and III grades in HP patients, whereas most were Genant I in controls. A logistic regression multivariate analysis was conducted in which age, BMI and parathyroid status were the independent variables, and morphometric vertebral fracture was the dependent variable, but none of these factors was a significant predictor of fracture in this population (OR 1.01, 95% CI 0.96-1.07, p=0.634 for age; OR 2.24, 95%CI 0.47-10.50, p=0.306 for the presence/absence of HP and OR 0.92, 95% CI 0.76-1.10, p=0.369 for BMI). CONCLUSION: The results of this study cannot ensure a higher risk of fragility vertebral fractures in postsurgical HP patients. Instead, we only observed higher Genant grade classification of the deformed vertebrae in our sample. |
format | Online Article Text |
id | pubmed-9816127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98161272023-01-07 Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism d’Alva, Catarina Brasil Barreto, André Rodrigues Façanha Nogueira-Barbosa, Marcello H. Arruda, Caio César Cavalcante Albuquerque, Áurea Maíla Praciano, Débora Mota Cordeiro Viana, Rodrigo Ponte Gadelha, Daniel Duarte Viana Jr, Antônio Brazil Moreira, Ilana Marques de Moura Filho, Francisco José Rodrigues Junqueira, Ana Flávia Torquato de Araújo Montenegro Jr, Renan Magalhães Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Hypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic skeletal changes have a negative impact on the fracture risk, it is not known. METHODS: Aiming to investigate the risk of insufficiency vertebral fractures in HP, defined using morphometric criteria, a consecutive sampling of 44 women with chronic postsurgical HP was compared to a control group of 44 adult healthy women, matched by age with patients. Vertebral fractures were analyzed by the semiquantitative Genant’s method followed by quantitative vertebral morphometry. RESULTS: Morphometric vertebral fractures were identified in 5/44 (11.4%) patients and in 3/44 (6.8%) controls (p=0.731). Most fractures were classified as Genant II and III grades in HP patients, whereas most were Genant I in controls. A logistic regression multivariate analysis was conducted in which age, BMI and parathyroid status were the independent variables, and morphometric vertebral fracture was the dependent variable, but none of these factors was a significant predictor of fracture in this population (OR 1.01, 95% CI 0.96-1.07, p=0.634 for age; OR 2.24, 95%CI 0.47-10.50, p=0.306 for the presence/absence of HP and OR 0.92, 95% CI 0.76-1.10, p=0.369 for BMI). CONCLUSION: The results of this study cannot ensure a higher risk of fragility vertebral fractures in postsurgical HP patients. Instead, we only observed higher Genant grade classification of the deformed vertebrae in our sample. Frontiers Media S.A. 2022-12-23 /pmc/articles/PMC9816127/ /pubmed/36619538 http://dx.doi.org/10.3389/fendo.2022.948435 Text en Copyright © 2022 d’Alva, Barreto, Nogueira-Barbosa, Arruda, Albuquerque, Praciano, Viana, Gadelha, Viana Jr, Moreira, Moura Filho, Junqueira and Montenegro Jr https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology d’Alva, Catarina Brasil Barreto, André Rodrigues Façanha Nogueira-Barbosa, Marcello H. Arruda, Caio César Cavalcante Albuquerque, Áurea Maíla Praciano, Débora Mota Cordeiro Viana, Rodrigo Ponte Gadelha, Daniel Duarte Viana Jr, Antônio Brazil Moreira, Ilana Marques de Moura Filho, Francisco José Rodrigues Junqueira, Ana Flávia Torquato de Araújo Montenegro Jr, Renan Magalhães Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
title | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
title_full | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
title_fullStr | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
title_full_unstemmed | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
title_short | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
title_sort | morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816127/ https://www.ncbi.nlm.nih.gov/pubmed/36619538 http://dx.doi.org/10.3389/fendo.2022.948435 |
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