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Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle

RATIONALE: The female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal hormones alter orexin or hypocretin peptide production and receptor activity. Depending on the estrous cycle phase, the transcription of prepro-orexin mRNA,...

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Autores principales: Kim, Hye Ji J., Dickie, Samuel A., Laprairie, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816302/
https://www.ncbi.nlm.nih.gov/pubmed/36571628
http://dx.doi.org/10.1007/s00213-022-06296-1
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author Kim, Hye Ji J.
Dickie, Samuel A.
Laprairie, Robert B.
author_facet Kim, Hye Ji J.
Dickie, Samuel A.
Laprairie, Robert B.
author_sort Kim, Hye Ji J.
collection PubMed
description RATIONALE: The female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal hormones alter orexin or hypocretin peptide production and receptor activity. Depending on the estrous cycle phase, the transcription of prepro-orexin mRNA, post-translational modification of orexin peptide, and abundance of orexin receptors change in a brain region-specific manner. The most dramatic changes occur in the hypothalamus, which is considered the starting point of the hypothalamic-pituitary–gonadal axis as well as the hub of orexin-producing neurons. Thus, hypothalamus-regulated behaviors, including arousal, feeding, reward processing, and the stress response depend on coordinated efforts between E2, progesterone, and the orexin system. Given the rise of orexin therapeutics for various neuropsychiatric conditions including insomnia and affective disorders, it is important to delineate the behavioral outcomes of this drug class in both sexes, as well as within different time points of the female reproductive cycle. OBJECTIVES: Summarize how the menstrual or estrous cycle affects orexin system functionality in animal models in order to predict how orexin pharmacotherapies exert varying degrees of behavioral effects across the dynamic hormonal milieu.
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spelling pubmed-98163022023-01-07 Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle Kim, Hye Ji J. Dickie, Samuel A. Laprairie, Robert B. Psychopharmacology (Berl) Review RATIONALE: The female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal hormones alter orexin or hypocretin peptide production and receptor activity. Depending on the estrous cycle phase, the transcription of prepro-orexin mRNA, post-translational modification of orexin peptide, and abundance of orexin receptors change in a brain region-specific manner. The most dramatic changes occur in the hypothalamus, which is considered the starting point of the hypothalamic-pituitary–gonadal axis as well as the hub of orexin-producing neurons. Thus, hypothalamus-regulated behaviors, including arousal, feeding, reward processing, and the stress response depend on coordinated efforts between E2, progesterone, and the orexin system. Given the rise of orexin therapeutics for various neuropsychiatric conditions including insomnia and affective disorders, it is important to delineate the behavioral outcomes of this drug class in both sexes, as well as within different time points of the female reproductive cycle. OBJECTIVES: Summarize how the menstrual or estrous cycle affects orexin system functionality in animal models in order to predict how orexin pharmacotherapies exert varying degrees of behavioral effects across the dynamic hormonal milieu. Springer Berlin Heidelberg 2022-12-26 2023 /pmc/articles/PMC9816302/ /pubmed/36571628 http://dx.doi.org/10.1007/s00213-022-06296-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kim, Hye Ji J.
Dickie, Samuel A.
Laprairie, Robert B.
Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
title Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
title_full Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
title_fullStr Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
title_full_unstemmed Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
title_short Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
title_sort estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816302/
https://www.ncbi.nlm.nih.gov/pubmed/36571628
http://dx.doi.org/10.1007/s00213-022-06296-1
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