Cargando…

Identification of homologous GluN subunits variants accelerates GRIN variants stratification

The clinical spectrum of GRIN-related neurodevelopmental disorders (GRD) results from gene- and variant-dependent primary alterations of the NMDA receptor, disturbing glutamatergic neurotransmission. Despite GRIN gene variants’ functional annotations being dually critical for stratification and prec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santos-Gómez, Ana, García-Recio, Adrián, Miguez-Cabello, Federico, Soto, David, Altafaj, Xavier, Olivella, Mireia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816381/ https://www.ncbi.nlm.nih.gov/pubmed/36619673 http://dx.doi.org/10.3389/fncel.2022.998719

Ejemplares similares

Paradigmatic De Novo GRIN1 Variants Recapitulate Pathophysiological Mechanisms Underlying GRIN1-Related Disorder Clinical Spectrum
por: Santos-Gómez, Ana, et al.
Publicado: (2021)

Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors
por: McClymont, David W., et al.
Publicado: (2012)

DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors
por: Grau, Cristina, et al.
Publicado: (2014)

Mg(2+) block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
por: Huang, Zhuo, et al.
Publicado: (2014)

Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors
por: Karakas, Erkan, et al.
Publicado: (2011)

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
por: Shipton, Olivia A., et al.
Publicado: (2014)

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening
por: Talukder, Iehab, et al.
Publicado: (2011)

GluN1 and GluN2A NMDA Receptor Subunits Increase in the Hippocampus during Memory Consolidation in the Rat
por: Cercato, Magali C., et al.
Publicado: (2017)

Altered Synaptic and Extrasynaptic NMDA Receptor Properties in Substantia Nigra Dopaminergic Neurons From Mice Lacking the GluN2D Subunit
por: Morris, Paul G., et al.
Publicado: (2018)

Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists
por: Rouzbeh, Nirvan, et al.
Publicado: (2023)

The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B
por: Tsang, Ka Hing, et al.
Publicado: (2014)

Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
por: Skrenkova, Kristyna, et al.
Publicado: (2019)

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences
por: McKay, Sean, et al.
Publicado: (2018)

Influence of GluN2 subunit identity on NMDA receptor function
por: Wyllie, D.J.A., et al.
Publicado: (2013)

Efavirenz restored NMDA receptor dysfunction and inhibited epileptic seizures in GluN2A/Grin2a mutant mice
por: Zhao, Teng, et al.
Publicado: (2023)

Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
por: Yakovlev, Aleksey V., et al.
Publicado: (2017)

The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures
por: Smaga, Irena, et al.
Publicado: (2021)

Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation
por: Cummings, Kirstie A., et al.
Publicado: (2016)

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
por: Grand, Teddy, et al.
Publicado: (2018)

Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine
por: Tarrés-Gatius, Mireia, et al.
Publicado: (2020)

GluN3A: An NMDA Receptor Subunit with Exquisite Properties and Functions
por: Kehoe, Laura A., et al.
Publicado: (2013)

Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia
por: Vinnakota, Chitra, et al.
Publicado: (2023)

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis
por: Üner, Aykut, et al.
Publicado: (2015)

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes
por: Shelkar, Gajanan P., et al.
Publicado: (2019)

GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases
por: Ladagu, Amany Digal, et al.
Publicado: (2023)

Selected single-nucleotide variants in GRIN1, GRIN2A, and GRIN2B encoding subunits of the NMDA receptor are not biomarkers of schizophrenia resistant to clozapine: exploratory study
por: Krzystanek, Marek, et al.
Publicado: (2020)

An Autism-Associated de novo Mutation in GluN2B Destabilizes Growing Dendrites by Promoting Retraction and Pruning
por: Bahry, Jacob A., et al.
Publicado: (2021)

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients
por: Mellone, Manuela, et al.
Publicado: (2015)

Functional assessment of the NMDA receptor variant GluN2A (R586K)
por: Marwick, Katie F.M., et al.
Publicado: (2017)

GluN2 Subunit-Dependent Redox Modulation of NMDA Receptor Activation by Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2020)

Corrigendum: An Autism-Associated de novo Mutation in GluN2B Destabilizes Growing Dendrites by Promoting Retraction and Pruning
por: Bahry, Jacob A., et al.
Publicado: (2022)

GluN2B but Not GluN2A for Basal Dendritic Growth of Cortical Pyramidal Neurons
por: Gonda, Steffen, et al.
Publicado: (2020)

GluN2A and GluN2B NMDA receptors use distinct allosteric routes
por: Tian, Meilin, et al.
Publicado: (2021)

Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors
por: Zeng, Yue, et al.
Publicado: (2022)

A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain
por: Warming, Hannah, et al.
Publicado: (2019)

Distinct roles of GRIN2A and GRIN2B variants in neurological conditions
por: Myers, Scott J, et al.
Publicado: (2019)

GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord
por: Hildebrand, Michael E., et al.
Publicado: (2014)

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors
por: Chopra, Divyan A., et al.
Publicado: (2017)

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors
por: Riou, Morgane, et al.
Publicado: (2012)

GluN2A Subunit-Containing NMDA Receptors Are the Preferential Neuronal Targets of Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sf7efdb9pp5f1o48bq7qmaslrm