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Human Endogenous Retroviruses: Friends and Foes in Urology Clinics

Human endogenous retroviruses (HERVs) are originated from ancient exogenous retroviruses, which infected human germ line cells millions of years ago. HERVs have generally lost their replication and retrotransposition abilities, but adopted physiological roles in human biology. Though mostly inactive...

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Autores principales: Lee, Sun-Kyung, Kim, Seung Hyun, Ahnn, Joohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816444/
https://www.ncbi.nlm.nih.gov/pubmed/36599336
http://dx.doi.org/10.5213/inj.2244284.142
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author Lee, Sun-Kyung
Kim, Seung Hyun
Ahnn, Joohong
author_facet Lee, Sun-Kyung
Kim, Seung Hyun
Ahnn, Joohong
author_sort Lee, Sun-Kyung
collection PubMed
description Human endogenous retroviruses (HERVs) are originated from ancient exogenous retroviruses, which infected human germ line cells millions of years ago. HERVs have generally lost their replication and retrotransposition abilities, but adopted physiological roles in human biology. Though mostly inactive, HERVs can be reactivated by internal and external factors such as inflammations and environmental conditions. Their aberrant expression can participate in various human malignancies with complex etiology. This review describes the features and functions of HERVs in urological subjects, such as urological cancers and human reproduction. It provides the current knowledge of the HERVs and useful insights helping practice in urology clinics.
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spelling pubmed-98164442023-01-11 Human Endogenous Retroviruses: Friends and Foes in Urology Clinics Lee, Sun-Kyung Kim, Seung Hyun Ahnn, Joohong Int Neurourol J Review Article Human endogenous retroviruses (HERVs) are originated from ancient exogenous retroviruses, which infected human germ line cells millions of years ago. HERVs have generally lost their replication and retrotransposition abilities, but adopted physiological roles in human biology. Though mostly inactive, HERVs can be reactivated by internal and external factors such as inflammations and environmental conditions. Their aberrant expression can participate in various human malignancies with complex etiology. This review describes the features and functions of HERVs in urological subjects, such as urological cancers and human reproduction. It provides the current knowledge of the HERVs and useful insights helping practice in urology clinics. Korean Continence Society 2022-12 2022-12-30 /pmc/articles/PMC9816444/ /pubmed/36599336 http://dx.doi.org/10.5213/inj.2244284.142 Text en Copyright © 2022 Korean Continence Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Sun-Kyung
Kim, Seung Hyun
Ahnn, Joohong
Human Endogenous Retroviruses: Friends and Foes in Urology Clinics
title Human Endogenous Retroviruses: Friends and Foes in Urology Clinics
title_full Human Endogenous Retroviruses: Friends and Foes in Urology Clinics
title_fullStr Human Endogenous Retroviruses: Friends and Foes in Urology Clinics
title_full_unstemmed Human Endogenous Retroviruses: Friends and Foes in Urology Clinics
title_short Human Endogenous Retroviruses: Friends and Foes in Urology Clinics
title_sort human endogenous retroviruses: friends and foes in urology clinics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816444/
https://www.ncbi.nlm.nih.gov/pubmed/36599336
http://dx.doi.org/10.5213/inj.2244284.142
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