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The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents

PURPOSE: Metabolic syndrome (MetS) is a state of chronic inflammation, and high-sensitivity C-reactive protein (hsCRP) indicates inflammation. This paper evaluates the associations between hsCRP and MetS and its components in Korean children and adolescents. METHODS: We analyzed the data of 1,247 su...

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Autores principales: Kim, Ji Hyun, Lim, Jung Sub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Pediatric Endocrinology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816469/
https://www.ncbi.nlm.nih.gov/pubmed/35798307
http://dx.doi.org/10.6065/apem.2142226.113
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author Kim, Ji Hyun
Lim, Jung Sub
author_facet Kim, Ji Hyun
Lim, Jung Sub
author_sort Kim, Ji Hyun
collection PubMed
description PURPOSE: Metabolic syndrome (MetS) is a state of chronic inflammation, and high-sensitivity C-reactive protein (hsCRP) indicates inflammation. This paper evaluates the associations between hsCRP and MetS and its components in Korean children and adolescents. METHODS: We analyzed the data of 1,247 subjects (633 males, 14.2±2.7 years) from the Korea National Health and Nutrition Examination Survey 2016–2017. This study defined MetS and its components using the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria. RESULTS: The mean hsCRP level was 0.86±1.57 mg/dL (median and interquartile range: 0.37 and 0.43 mg/dL). Subjects with MetS had higher hsCRP level than subjects without MetS (geometric mean: 1.08 mg/dL vs. 0.46 mg/dL, p<0.001). With a higher quartile value of hsCRP, the prevalence of MetS increased. Compared to the lowest quartile, the odds ratio (OR) for MetS in the highest quartile was 7.34 (3.07–17.55) after adjusting for age and sex. In the top quartile of hsCRP, the risk of abdominal obesity and low HDL was high after adjusting for age, sex, and other components of MetS. Additionally, the OR for prediabetes (HbA1c ≥5.7%) in the highest quartile was 2.70. CONCLUSIONS: Serum hsCRP level was positively associated with MetS and prediabetes using NCEP-ATP III criteria. Among the MetS components, abdominal obesity and low HDL were highly correlated with hsCRP in Korean children and adolescents.
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spelling pubmed-98164692023-01-11 The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents Kim, Ji Hyun Lim, Jung Sub Ann Pediatr Endocrinol Metab Original Article PURPOSE: Metabolic syndrome (MetS) is a state of chronic inflammation, and high-sensitivity C-reactive protein (hsCRP) indicates inflammation. This paper evaluates the associations between hsCRP and MetS and its components in Korean children and adolescents. METHODS: We analyzed the data of 1,247 subjects (633 males, 14.2±2.7 years) from the Korea National Health and Nutrition Examination Survey 2016–2017. This study defined MetS and its components using the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria. RESULTS: The mean hsCRP level was 0.86±1.57 mg/dL (median and interquartile range: 0.37 and 0.43 mg/dL). Subjects with MetS had higher hsCRP level than subjects without MetS (geometric mean: 1.08 mg/dL vs. 0.46 mg/dL, p<0.001). With a higher quartile value of hsCRP, the prevalence of MetS increased. Compared to the lowest quartile, the odds ratio (OR) for MetS in the highest quartile was 7.34 (3.07–17.55) after adjusting for age and sex. In the top quartile of hsCRP, the risk of abdominal obesity and low HDL was high after adjusting for age, sex, and other components of MetS. Additionally, the OR for prediabetes (HbA1c ≥5.7%) in the highest quartile was 2.70. CONCLUSIONS: Serum hsCRP level was positively associated with MetS and prediabetes using NCEP-ATP III criteria. Among the MetS components, abdominal obesity and low HDL were highly correlated with hsCRP in Korean children and adolescents. Korean Society of Pediatric Endocrinology 2022-12 2022-06-28 /pmc/articles/PMC9816469/ /pubmed/35798307 http://dx.doi.org/10.6065/apem.2142226.113 Text en © 2022 Annals of Pediatric Endocrinology & Metabolism https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Ji Hyun
Lim, Jung Sub
The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents
title The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents
title_full The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents
title_fullStr The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents
title_full_unstemmed The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents
title_short The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents
title_sort association between c-reactive protein, metabolic syndrome, and prediabetes in korean children and adolescents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816469/
https://www.ncbi.nlm.nih.gov/pubmed/35798307
http://dx.doi.org/10.6065/apem.2142226.113
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