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A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients
Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evidence approach for assessing oral toxicity was cha...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816657/ https://www.ncbi.nlm.nih.gov/pubmed/36619289 http://dx.doi.org/10.1016/j.crtox.2022.100100 |
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| author | Kojima, Hajime Nakada, Tokio Yagami, Akiko Todo, Hiroaki Nishimura, Jihei Yagi, Mio Yamamoto, Keiko Sugiyama, Mariko Ikarashi, Yoshiaki Sakaguchi, Hitoshi Yamaguchi, Masahiko Hirota, Morihiko Aizawa, Sakiko Nakagawa, Shota Hagino, Shigenobu Hatao, Masato |
| author_facet | Kojima, Hajime Nakada, Tokio Yagami, Akiko Todo, Hiroaki Nishimura, Jihei Yagi, Mio Yamamoto, Keiko Sugiyama, Mariko Ikarashi, Yoshiaki Sakaguchi, Hitoshi Yamaguchi, Masahiko Hirota, Morihiko Aizawa, Sakiko Nakagawa, Shota Hagino, Shigenobu Hatao, Masato |
| author_sort | Kojima, Hajime |
| collection | PubMed |
| description | Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evidence approach for assessing oral toxicity was challenged. This approach used a combination of safety data, including a neutral red uptake cytotoxicity assay using BALB/c3T3 cells (3T3-NRU cytotoxicity assay), which can assess the acute oral toxicity of quasi-drugs or cosmetic ingredients. We conclude that the step-by-step approach can be used to assess test substances that cause low acute oral toxicity, such as the median lethal dose (LD 50) > 2000 mg/kg, thereby avoiding animal testing. |
| format | Online Article Text |
| id | pubmed-9816657 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98166572023-01-07 A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients Kojima, Hajime Nakada, Tokio Yagami, Akiko Todo, Hiroaki Nishimura, Jihei Yagi, Mio Yamamoto, Keiko Sugiyama, Mariko Ikarashi, Yoshiaki Sakaguchi, Hitoshi Yamaguchi, Masahiko Hirota, Morihiko Aizawa, Sakiko Nakagawa, Shota Hagino, Shigenobu Hatao, Masato Curr Res Toxicol Article Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evidence approach for assessing oral toxicity was challenged. This approach used a combination of safety data, including a neutral red uptake cytotoxicity assay using BALB/c3T3 cells (3T3-NRU cytotoxicity assay), which can assess the acute oral toxicity of quasi-drugs or cosmetic ingredients. We conclude that the step-by-step approach can be used to assess test substances that cause low acute oral toxicity, such as the median lethal dose (LD 50) > 2000 mg/kg, thereby avoiding animal testing. Elsevier 2022-12-23 /pmc/articles/PMC9816657/ /pubmed/36619289 http://dx.doi.org/10.1016/j.crtox.2022.100100 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Kojima, Hajime Nakada, Tokio Yagami, Akiko Todo, Hiroaki Nishimura, Jihei Yagi, Mio Yamamoto, Keiko Sugiyama, Mariko Ikarashi, Yoshiaki Sakaguchi, Hitoshi Yamaguchi, Masahiko Hirota, Morihiko Aizawa, Sakiko Nakagawa, Shota Hagino, Shigenobu Hatao, Masato A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients |
| title | A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients |
| title_full | A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients |
| title_fullStr | A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients |
| title_full_unstemmed | A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients |
| title_short | A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients |
| title_sort | step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816657/ https://www.ncbi.nlm.nih.gov/pubmed/36619289 http://dx.doi.org/10.1016/j.crtox.2022.100100 |
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