Cargando…

A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19

BACKGROUND/AIMS: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19). METHODS: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Baek, Moon Seong, Choi, Seong-Ho, Kim, Won-Young, Kim, Min-Chul, Joo, Eun-Jeong, Lee, Mi Suk, Kim, Hyun Ah, Jung, Sook In, Nae, Yu Shi, Kim, Bongyoung, Lim, Yaeji, Chung, Jin-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816687/
https://www.ncbi.nlm.nih.gov/pubmed/36281537
http://dx.doi.org/10.3904/kjim.2022.050
_version_ 1784864592586866688
author Baek, Moon Seong
Choi, Seong-Ho
Kim, Won-Young
Kim, Min-Chul
Joo, Eun-Jeong
Lee, Mi Suk
Kim, Hyun Ah
Jung, Sook In
Nae, Yu Shi
Kim, Bongyoung
Lim, Yaeji
Chung, Jin-Won
author_facet Baek, Moon Seong
Choi, Seong-Ho
Kim, Won-Young
Kim, Min-Chul
Joo, Eun-Jeong
Lee, Mi Suk
Kim, Hyun Ah
Jung, Sook In
Nae, Yu Shi
Kim, Bongyoung
Lim, Yaeji
Chung, Jin-Won
author_sort Baek, Moon Seong
collection PubMed
description BACKGROUND/AIMS: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19). METHODS: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient follow-up visit. Between January 11 and March 9, 2021 (study period), residual symptom investigations, chest computed tomography (CT) scans, pulmonary function tests (PFT), and neutralizing antibody tests (NAb) were performed at the outpatient visit (cross-sectional design). Additionally, data from patients who already had follow-up outpatient visits before the study period were collected retrospectively. RESULTS: Investigation of residual symptoms, chest CT scans, PFT, and NAb were performed in 84, 35, 31, and 27 patients, respectively. After 6 months, chest discomfort and dyspnea persisted in 26.7% (4/15) and 33.3% (5/15) patients, respectively, and 40.0% (6/15) and 26.7% (4/15) patients experienced financial loss and emotional distress, respectively. When the ratio of later CT score to previous ones was calculated for each patient between three different time intervals (1–14, 15–60, and 61–365 days), the median values were 0.65 (the second interval to the first), 0.39 (the third to the second), and 0.20 (the third to the first), indicating that CT score decreases with time. In the high-severity group, the ratio was lower than in the low-severity group. CONCLUSIONS: In COVID-19 survivors, chest CT score recovers over time, but recovery is slower in severely ill patients. Subjects complained of various ongoing symptoms and socioeconomic problems for several months after recovery.
format Online
Article
Text
id pubmed-9816687
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Korean Association of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-98166872023-01-18 A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 Baek, Moon Seong Choi, Seong-Ho Kim, Won-Young Kim, Min-Chul Joo, Eun-Jeong Lee, Mi Suk Kim, Hyun Ah Jung, Sook In Nae, Yu Shi Kim, Bongyoung Lim, Yaeji Chung, Jin-Won Korean J Intern Med Original Article BACKGROUND/AIMS: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19). METHODS: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient follow-up visit. Between January 11 and March 9, 2021 (study period), residual symptom investigations, chest computed tomography (CT) scans, pulmonary function tests (PFT), and neutralizing antibody tests (NAb) were performed at the outpatient visit (cross-sectional design). Additionally, data from patients who already had follow-up outpatient visits before the study period were collected retrospectively. RESULTS: Investigation of residual symptoms, chest CT scans, PFT, and NAb were performed in 84, 35, 31, and 27 patients, respectively. After 6 months, chest discomfort and dyspnea persisted in 26.7% (4/15) and 33.3% (5/15) patients, respectively, and 40.0% (6/15) and 26.7% (4/15) patients experienced financial loss and emotional distress, respectively. When the ratio of later CT score to previous ones was calculated for each patient between three different time intervals (1–14, 15–60, and 61–365 days), the median values were 0.65 (the second interval to the first), 0.39 (the third to the second), and 0.20 (the third to the first), indicating that CT score decreases with time. In the high-severity group, the ratio was lower than in the low-severity group. CONCLUSIONS: In COVID-19 survivors, chest CT score recovers over time, but recovery is slower in severely ill patients. Subjects complained of various ongoing symptoms and socioeconomic problems for several months after recovery. Korean Association of Internal Medicine 2023-01 2022-10-25 /pmc/articles/PMC9816687/ /pubmed/36281537 http://dx.doi.org/10.3904/kjim.2022.050 Text en Copyright © 2022 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Baek, Moon Seong
Choi, Seong-Ho
Kim, Won-Young
Kim, Min-Chul
Joo, Eun-Jeong
Lee, Mi Suk
Kim, Hyun Ah
Jung, Sook In
Nae, Yu Shi
Kim, Bongyoung
Lim, Yaeji
Chung, Jin-Won
A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
title A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
title_full A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
title_fullStr A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
title_full_unstemmed A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
title_short A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
title_sort study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with covid-19
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816687/
https://www.ncbi.nlm.nih.gov/pubmed/36281537
http://dx.doi.org/10.3904/kjim.2022.050
work_keys_str_mv AT baekmoonseong astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT choiseongho astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimwonyoung astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimminchul astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT jooeunjeong astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT leemisuk astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimhyunah astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT jungsookin astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT naeyushi astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimbongyoung astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT limyaeji astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT chungjinwon astudyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT baekmoonseong studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT choiseongho studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimwonyoung studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimminchul studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT jooeunjeong studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT leemisuk studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimhyunah studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT jungsookin studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT naeyushi studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT kimbongyoung studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT limyaeji studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19
AT chungjinwon studyonchangesinlungfunctionneutralizingantibodiesandsymptomsofadultpatientshospitalizedwithcovid19