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A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
BACKGROUND/AIMS: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19). METHODS: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient fo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association of Internal Medicine
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816687/ https://www.ncbi.nlm.nih.gov/pubmed/36281537 http://dx.doi.org/10.3904/kjim.2022.050 |
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author | Baek, Moon Seong Choi, Seong-Ho Kim, Won-Young Kim, Min-Chul Joo, Eun-Jeong Lee, Mi Suk Kim, Hyun Ah Jung, Sook In Nae, Yu Shi Kim, Bongyoung Lim, Yaeji Chung, Jin-Won |
author_facet | Baek, Moon Seong Choi, Seong-Ho Kim, Won-Young Kim, Min-Chul Joo, Eun-Jeong Lee, Mi Suk Kim, Hyun Ah Jung, Sook In Nae, Yu Shi Kim, Bongyoung Lim, Yaeji Chung, Jin-Won |
author_sort | Baek, Moon Seong |
collection | PubMed |
description | BACKGROUND/AIMS: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19). METHODS: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient follow-up visit. Between January 11 and March 9, 2021 (study period), residual symptom investigations, chest computed tomography (CT) scans, pulmonary function tests (PFT), and neutralizing antibody tests (NAb) were performed at the outpatient visit (cross-sectional design). Additionally, data from patients who already had follow-up outpatient visits before the study period were collected retrospectively. RESULTS: Investigation of residual symptoms, chest CT scans, PFT, and NAb were performed in 84, 35, 31, and 27 patients, respectively. After 6 months, chest discomfort and dyspnea persisted in 26.7% (4/15) and 33.3% (5/15) patients, respectively, and 40.0% (6/15) and 26.7% (4/15) patients experienced financial loss and emotional distress, respectively. When the ratio of later CT score to previous ones was calculated for each patient between three different time intervals (1–14, 15–60, and 61–365 days), the median values were 0.65 (the second interval to the first), 0.39 (the third to the second), and 0.20 (the third to the first), indicating that CT score decreases with time. In the high-severity group, the ratio was lower than in the low-severity group. CONCLUSIONS: In COVID-19 survivors, chest CT score recovers over time, but recovery is slower in severely ill patients. Subjects complained of various ongoing symptoms and socioeconomic problems for several months after recovery. |
format | Online Article Text |
id | pubmed-9816687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-98166872023-01-18 A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 Baek, Moon Seong Choi, Seong-Ho Kim, Won-Young Kim, Min-Chul Joo, Eun-Jeong Lee, Mi Suk Kim, Hyun Ah Jung, Sook In Nae, Yu Shi Kim, Bongyoung Lim, Yaeji Chung, Jin-Won Korean J Intern Med Original Article BACKGROUND/AIMS: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19). METHODS: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient follow-up visit. Between January 11 and March 9, 2021 (study period), residual symptom investigations, chest computed tomography (CT) scans, pulmonary function tests (PFT), and neutralizing antibody tests (NAb) were performed at the outpatient visit (cross-sectional design). Additionally, data from patients who already had follow-up outpatient visits before the study period were collected retrospectively. RESULTS: Investigation of residual symptoms, chest CT scans, PFT, and NAb were performed in 84, 35, 31, and 27 patients, respectively. After 6 months, chest discomfort and dyspnea persisted in 26.7% (4/15) and 33.3% (5/15) patients, respectively, and 40.0% (6/15) and 26.7% (4/15) patients experienced financial loss and emotional distress, respectively. When the ratio of later CT score to previous ones was calculated for each patient between three different time intervals (1–14, 15–60, and 61–365 days), the median values were 0.65 (the second interval to the first), 0.39 (the third to the second), and 0.20 (the third to the first), indicating that CT score decreases with time. In the high-severity group, the ratio was lower than in the low-severity group. CONCLUSIONS: In COVID-19 survivors, chest CT score recovers over time, but recovery is slower in severely ill patients. Subjects complained of various ongoing symptoms and socioeconomic problems for several months after recovery. Korean Association of Internal Medicine 2023-01 2022-10-25 /pmc/articles/PMC9816687/ /pubmed/36281537 http://dx.doi.org/10.3904/kjim.2022.050 Text en Copyright © 2022 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Baek, Moon Seong Choi, Seong-Ho Kim, Won-Young Kim, Min-Chul Joo, Eun-Jeong Lee, Mi Suk Kim, Hyun Ah Jung, Sook In Nae, Yu Shi Kim, Bongyoung Lim, Yaeji Chung, Jin-Won A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 |
title | A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 |
title_full | A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 |
title_fullStr | A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 |
title_full_unstemmed | A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 |
title_short | A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 |
title_sort | study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with covid-19 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816687/ https://www.ncbi.nlm.nih.gov/pubmed/36281537 http://dx.doi.org/10.3904/kjim.2022.050 |
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