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Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease
BACKGROUND: This study aimed to explore the association between deep medullary veins (DMVs) and the neuroimaging burden of cerebral small vessel disease (CSVD). METHODS: In this cross-sectional study based on a retrospective analysis, a total of 248 patients (183 males and 65 females; mean age ± sta...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816744/ https://www.ncbi.nlm.nih.gov/pubmed/36620153 http://dx.doi.org/10.21037/qims-22-264 |
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author | Yin, Xuyang Han, Yan Cao, Xin Zeng, Yanwei Tang, Yuping Ding, Ding Zhang, Jun |
author_facet | Yin, Xuyang Han, Yan Cao, Xin Zeng, Yanwei Tang, Yuping Ding, Ding Zhang, Jun |
author_sort | Yin, Xuyang |
collection | PubMed |
description | BACKGROUND: This study aimed to explore the association between deep medullary veins (DMVs) and the neuroimaging burden of cerebral small vessel disease (CSVD). METHODS: In this cross-sectional study based on a retrospective analysis, a total of 248 patients (183 males and 65 females; mean age ± standard deviation, 69.5±14.8 years) diagnosed with CSVD with complete imaging and clinical data were enrolled. Neuroimaging markers of CSVD, including white matter hyperintensities, lacunes, prominent perivascular spaces (PVSs), and cerebral microbleeds (CMBs), were identified, and the total burden of CSVD was scored. Both DMV number and DMV score were used for assessment using susceptibility-weighted imaging (SWI). RESULTS: With the exception of perivascular spaces, more severe neuroimaging markers were observed in patients with a higher DMV score. After adjustments were made for age and body mass index (BMI), a higher DMV score (β=1.39; P<0.001) and smaller DMV number (β=–2.55; P=0.001) were associated with an increased CSVD burden. The degree of CMBs was independently correlated with both DMV score (β=1.60; P<0.001) and DMV number (β=–2.27; P=0.009). The association between lacunes and DMV score was also significant (β=0.97; P=0.026). CONCLUSIONS: Both DMV score and DMV number are potential imaging indicators of CSVD. |
format | Online Article Text |
id | pubmed-9816744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-98167442023-01-07 Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease Yin, Xuyang Han, Yan Cao, Xin Zeng, Yanwei Tang, Yuping Ding, Ding Zhang, Jun Quant Imaging Med Surg Original Article BACKGROUND: This study aimed to explore the association between deep medullary veins (DMVs) and the neuroimaging burden of cerebral small vessel disease (CSVD). METHODS: In this cross-sectional study based on a retrospective analysis, a total of 248 patients (183 males and 65 females; mean age ± standard deviation, 69.5±14.8 years) diagnosed with CSVD with complete imaging and clinical data were enrolled. Neuroimaging markers of CSVD, including white matter hyperintensities, lacunes, prominent perivascular spaces (PVSs), and cerebral microbleeds (CMBs), were identified, and the total burden of CSVD was scored. Both DMV number and DMV score were used for assessment using susceptibility-weighted imaging (SWI). RESULTS: With the exception of perivascular spaces, more severe neuroimaging markers were observed in patients with a higher DMV score. After adjustments were made for age and body mass index (BMI), a higher DMV score (β=1.39; P<0.001) and smaller DMV number (β=–2.55; P=0.001) were associated with an increased CSVD burden. The degree of CMBs was independently correlated with both DMV score (β=1.60; P<0.001) and DMV number (β=–2.27; P=0.009). The association between lacunes and DMV score was also significant (β=0.97; P=0.026). CONCLUSIONS: Both DMV score and DMV number are potential imaging indicators of CSVD. AME Publishing Company 2022-10-26 2023-01-01 /pmc/articles/PMC9816744/ /pubmed/36620153 http://dx.doi.org/10.21037/qims-22-264 Text en 2023 Quantitative Imaging in Medicine and Surgery. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Yin, Xuyang Han, Yan Cao, Xin Zeng, Yanwei Tang, Yuping Ding, Ding Zhang, Jun Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease |
title | Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease |
title_full | Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease |
title_fullStr | Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease |
title_full_unstemmed | Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease |
title_short | Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease |
title_sort | association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816744/ https://www.ncbi.nlm.nih.gov/pubmed/36620153 http://dx.doi.org/10.21037/qims-22-264 |
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