The role of NLRP3 inflammasome in digestive system malignancy

Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In...

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Autores principales: Sun, Cen-Cen, Li, Li, Tao, Hou-Quan, Jiang, Zhi-Chen, Wang, Liang, Wang, Hui-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816811/
https://www.ncbi.nlm.nih.gov/pubmed/36619871
http://dx.doi.org/10.3389/fcell.2022.1051612
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author Sun, Cen-Cen
Li, Li
Tao, Hou-Quan
Jiang, Zhi-Chen
Wang, Liang
Wang, Hui-Ju
author_facet Sun, Cen-Cen
Li, Li
Tao, Hou-Quan
Jiang, Zhi-Chen
Wang, Liang
Wang, Hui-Ju
author_sort Sun, Cen-Cen
collection PubMed
description Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In this paper, we reviewed its pro-tumorigenic and anti-tumorigenic properties in different types of digestive system malignancy depending on the types of cells, tissues and organs involved, which would provide promising avenue for exploring new anti-cancer therapies.
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spelling pubmed-98168112023-01-07 The role of NLRP3 inflammasome in digestive system malignancy Sun, Cen-Cen Li, Li Tao, Hou-Quan Jiang, Zhi-Chen Wang, Liang Wang, Hui-Ju Front Cell Dev Biol Cell and Developmental Biology Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In this paper, we reviewed its pro-tumorigenic and anti-tumorigenic properties in different types of digestive system malignancy depending on the types of cells, tissues and organs involved, which would provide promising avenue for exploring new anti-cancer therapies. Frontiers Media S.A. 2022-12-23 /pmc/articles/PMC9816811/ /pubmed/36619871 http://dx.doi.org/10.3389/fcell.2022.1051612 Text en Copyright © 2022 Sun, Li, Tao, Jiang, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Sun, Cen-Cen
Li, Li
Tao, Hou-Quan
Jiang, Zhi-Chen
Wang, Liang
Wang, Hui-Ju
The role of NLRP3 inflammasome in digestive system malignancy
title The role of NLRP3 inflammasome in digestive system malignancy
title_full The role of NLRP3 inflammasome in digestive system malignancy
title_fullStr The role of NLRP3 inflammasome in digestive system malignancy
title_full_unstemmed The role of NLRP3 inflammasome in digestive system malignancy
title_short The role of NLRP3 inflammasome in digestive system malignancy
title_sort role of nlrp3 inflammasome in digestive system malignancy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816811/
https://www.ncbi.nlm.nih.gov/pubmed/36619871
http://dx.doi.org/10.3389/fcell.2022.1051612
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