Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies

Genomic profiling revealed the identity of at least 5 subtypes of diffuse large B-cell lymphoma (DLBCL), including the MCD/C5 cluster characterized by aberrations in MYD88, BCL2, PRDM1, and/or SPIB. We generated mouse models harboring B cell–specific Prdm1 or Spib aberrations on the background of on...

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Detalles Bibliográficos
Autores principales: Flümann, Ruth, Hansen, Julia, Pelzer, Benedikt W., Nieper, Pascal, Lohmann, Tim, Kisis, Ilmars, Riet, Tobias, Kohlhas, Viktoria, Nguyen, Phuong-Hien, Peifer, Martin, Abedpour, Nima, Bosco, Graziella, Thomas, Roman K., Kochanek, Moritz, Knüfer, Jacqueline, Jonigkeit, Lorenz, Beleggia, Filippo, Holzem, Alessandra, Büttner, Reinhard, Lohneis, Philipp, Meinel, Jörn, Ortmann, Monika, Persigehl, Thorsten, Hallek, Michael, Calado, Dinis Pedro, Chmielewski, Markus, Klein, Sebastian, Göthert, Joachim R., Chapuy, Bjoern, Zevnik, Branko, Wunderlich, F. Thomas, von Tresckow, Bastian, Jachimowicz, Ron D., Melnick, Ari M., Reinhardt, Hans Christian, Knittel, Gero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816818/
https://www.ncbi.nlm.nih.gov/pubmed/36346827
http://dx.doi.org/10.1158/2643-3230.BCD-22-0007

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