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Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature

BACKGROUND: Metastatic germ cell tumors particularly in the bone are rare entities. They occur in young men and classified in the group of poor prognosis. Bone metastases are responsible for a significant functional handicap and a deep alteration in the quality of life of young patients. Metastatic...

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Autores principales: Chebli, Najwa, Dahiri, Mustapha, Ahmut, Halima, El Aamraoui, Meryem, Lannaz, Saad, El Ghissassi, Ibrahim, Boutayeb, Saber, Mrabti, Hind, Errihani, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816831/
https://www.ncbi.nlm.nih.gov/pubmed/36618797
http://dx.doi.org/10.21037/atm-2022-51
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author Chebli, Najwa
Dahiri, Mustapha
Ahmut, Halima
El Aamraoui, Meryem
Lannaz, Saad
El Ghissassi, Ibrahim
Boutayeb, Saber
Mrabti, Hind
Errihani, Hassan
author_facet Chebli, Najwa
Dahiri, Mustapha
Ahmut, Halima
El Aamraoui, Meryem
Lannaz, Saad
El Ghissassi, Ibrahim
Boutayeb, Saber
Mrabti, Hind
Errihani, Hassan
author_sort Chebli, Najwa
collection PubMed
description BACKGROUND: Metastatic germ cell tumors particularly in the bone are rare entities. They occur in young men and classified in the group of poor prognosis. Bone metastases are responsible for a significant functional handicap and a deep alteration in the quality of life of young patients. Metastatic germ cell tumors are rare entities with a high cure rate due to their extreme chemosensitivity. To our knowledge, epidural metastasis of this tumor has not yet been reported in the English medical literature. Tumors of the breast, lung and prostate are the most notorious for metastasizing in the epidural-spinal space. CASE DESCRIPTION: We report a clinical case of spinal cord compression secondary to metastasis in the spinal epidural space of a testicular germ cell tumor in a 23-year-old. Patient whose evolution was marked by a decrease in tumor markers and a clear clinical improvement with disappearance of lower back pain and horsetail syndrome after starting the treatment with decompressive radiotherapy and chemotherapy based on bleomycin cisplatin and etoposide. CONCLUSIONS: Through this, we want to emphasize that an epidural metastasis of this tumor is possible, and that it must be part of the diagnoses to be evoked in the face of metastatic spinal cord compression, which potentially allows to avoid a significant functional handicap and a profound alteration in the quality life of young patients.
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spelling pubmed-98168312023-01-07 Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature Chebli, Najwa Dahiri, Mustapha Ahmut, Halima El Aamraoui, Meryem Lannaz, Saad El Ghissassi, Ibrahim Boutayeb, Saber Mrabti, Hind Errihani, Hassan Ann Transl Med Case Report BACKGROUND: Metastatic germ cell tumors particularly in the bone are rare entities. They occur in young men and classified in the group of poor prognosis. Bone metastases are responsible for a significant functional handicap and a deep alteration in the quality of life of young patients. Metastatic germ cell tumors are rare entities with a high cure rate due to their extreme chemosensitivity. To our knowledge, epidural metastasis of this tumor has not yet been reported in the English medical literature. Tumors of the breast, lung and prostate are the most notorious for metastasizing in the epidural-spinal space. CASE DESCRIPTION: We report a clinical case of spinal cord compression secondary to metastasis in the spinal epidural space of a testicular germ cell tumor in a 23-year-old. Patient whose evolution was marked by a decrease in tumor markers and a clear clinical improvement with disappearance of lower back pain and horsetail syndrome after starting the treatment with decompressive radiotherapy and chemotherapy based on bleomycin cisplatin and etoposide. CONCLUSIONS: Through this, we want to emphasize that an epidural metastasis of this tumor is possible, and that it must be part of the diagnoses to be evoked in the face of metastatic spinal cord compression, which potentially allows to avoid a significant functional handicap and a profound alteration in the quality life of young patients. AME Publishing Company 2022-12 /pmc/articles/PMC9816831/ /pubmed/36618797 http://dx.doi.org/10.21037/atm-2022-51 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Case Report
Chebli, Najwa
Dahiri, Mustapha
Ahmut, Halima
El Aamraoui, Meryem
Lannaz, Saad
El Ghissassi, Ibrahim
Boutayeb, Saber
Mrabti, Hind
Errihani, Hassan
Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature
title Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature
title_full Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature
title_fullStr Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature
title_full_unstemmed Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature
title_short Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature
title_sort symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816831/
https://www.ncbi.nlm.nih.gov/pubmed/36618797
http://dx.doi.org/10.21037/atm-2022-51
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