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Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration

Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficie...

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Autores principales: Chen, Hai‐Wei, Zhou, Jian‐Wei, Zhang, Guang‐Zhi, Luo, Zhang‐Bin, Li, Lei, Kang, Xue‐Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816935/
https://www.ncbi.nlm.nih.gov/pubmed/36193577
http://dx.doi.org/10.1111/cpr.13338
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author Chen, Hai‐Wei
Zhou, Jian‐Wei
Zhang, Guang‐Zhi
Luo, Zhang‐Bin
Li, Lei
Kang, Xue‐Wen
author_facet Chen, Hai‐Wei
Zhou, Jian‐Wei
Zhang, Guang‐Zhi
Luo, Zhang‐Bin
Li, Lei
Kang, Xue‐Wen
author_sort Chen, Hai‐Wei
collection PubMed
description Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficiency, and genetics, lead to reduced extracellular matrix (ECM) synthesis by intervertebral disc (IVD) cells and accelerate IDD progression. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that plays a vital role in diverse degenerative diseases. Recent studies have shown that mTOR signalling is involved in the regulation of autophagy, oxidative stress, inflammatory responses, ECM homeostasis, cellular senescence, and apoptosis in IVD cells. Accordingly, we reviewed the mechanism of mTOR signalling in the pathogenesis of IDD to provide innovative ideas for future research and IDD treatment.
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spelling pubmed-98169352023-01-06 Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration Chen, Hai‐Wei Zhou, Jian‐Wei Zhang, Guang‐Zhi Luo, Zhang‐Bin Li, Lei Kang, Xue‐Wen Cell Prolif Reviews Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficiency, and genetics, lead to reduced extracellular matrix (ECM) synthesis by intervertebral disc (IVD) cells and accelerate IDD progression. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that plays a vital role in diverse degenerative diseases. Recent studies have shown that mTOR signalling is involved in the regulation of autophagy, oxidative stress, inflammatory responses, ECM homeostasis, cellular senescence, and apoptosis in IVD cells. Accordingly, we reviewed the mechanism of mTOR signalling in the pathogenesis of IDD to provide innovative ideas for future research and IDD treatment. John Wiley and Sons Inc. 2022-10-03 /pmc/articles/PMC9816935/ /pubmed/36193577 http://dx.doi.org/10.1111/cpr.13338 Text en © 2022 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Chen, Hai‐Wei
Zhou, Jian‐Wei
Zhang, Guang‐Zhi
Luo, Zhang‐Bin
Li, Lei
Kang, Xue‐Wen
Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
title Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
title_full Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
title_fullStr Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
title_full_unstemmed Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
title_short Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
title_sort emerging role and therapeutic implication of mtor signalling in intervertebral disc degeneration
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816935/
https://www.ncbi.nlm.nih.gov/pubmed/36193577
http://dx.doi.org/10.1111/cpr.13338
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