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Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficie...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816935/ https://www.ncbi.nlm.nih.gov/pubmed/36193577 http://dx.doi.org/10.1111/cpr.13338 |
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author | Chen, Hai‐Wei Zhou, Jian‐Wei Zhang, Guang‐Zhi Luo, Zhang‐Bin Li, Lei Kang, Xue‐Wen |
author_facet | Chen, Hai‐Wei Zhou, Jian‐Wei Zhang, Guang‐Zhi Luo, Zhang‐Bin Li, Lei Kang, Xue‐Wen |
author_sort | Chen, Hai‐Wei |
collection | PubMed |
description | Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficiency, and genetics, lead to reduced extracellular matrix (ECM) synthesis by intervertebral disc (IVD) cells and accelerate IDD progression. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that plays a vital role in diverse degenerative diseases. Recent studies have shown that mTOR signalling is involved in the regulation of autophagy, oxidative stress, inflammatory responses, ECM homeostasis, cellular senescence, and apoptosis in IVD cells. Accordingly, we reviewed the mechanism of mTOR signalling in the pathogenesis of IDD to provide innovative ideas for future research and IDD treatment. |
format | Online Article Text |
id | pubmed-9816935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98169352023-01-06 Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration Chen, Hai‐Wei Zhou, Jian‐Wei Zhang, Guang‐Zhi Luo, Zhang‐Bin Li, Lei Kang, Xue‐Wen Cell Prolif Reviews Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficiency, and genetics, lead to reduced extracellular matrix (ECM) synthesis by intervertebral disc (IVD) cells and accelerate IDD progression. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that plays a vital role in diverse degenerative diseases. Recent studies have shown that mTOR signalling is involved in the regulation of autophagy, oxidative stress, inflammatory responses, ECM homeostasis, cellular senescence, and apoptosis in IVD cells. Accordingly, we reviewed the mechanism of mTOR signalling in the pathogenesis of IDD to provide innovative ideas for future research and IDD treatment. John Wiley and Sons Inc. 2022-10-03 /pmc/articles/PMC9816935/ /pubmed/36193577 http://dx.doi.org/10.1111/cpr.13338 Text en © 2022 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Chen, Hai‐Wei Zhou, Jian‐Wei Zhang, Guang‐Zhi Luo, Zhang‐Bin Li, Lei Kang, Xue‐Wen Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration |
title | Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration |
title_full | Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration |
title_fullStr | Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration |
title_full_unstemmed | Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration |
title_short | Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration |
title_sort | emerging role and therapeutic implication of mtor signalling in intervertebral disc degeneration |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816935/ https://www.ncbi.nlm.nih.gov/pubmed/36193577 http://dx.doi.org/10.1111/cpr.13338 |
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