Mitochondrial Autophagy in Ischemic Aged Livers

Mitochondrial autophagy (mitophagy) is a central catabolic event for mitochondrial quality control. Defective or insufficient mitophagy, thus, can result in mitochondrial dysfunction, and ultimately cell death. There is a strong causal relationship between ischemia/reperfusion (I/R) injury and mitoc...

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Detalles Bibliográficos
Autores principales: Kim, Jae-Sung, Chapman, William C., Lin, Yiing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816943/
https://www.ncbi.nlm.nih.gov/pubmed/36552847
http://dx.doi.org/10.3390/cells11244083
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author Kim, Jae-Sung
Chapman, William C.
Lin, Yiing
author_facet Kim, Jae-Sung
Chapman, William C.
Lin, Yiing
author_sort Kim, Jae-Sung
collection PubMed
description Mitochondrial autophagy (mitophagy) is a central catabolic event for mitochondrial quality control. Defective or insufficient mitophagy, thus, can result in mitochondrial dysfunction, and ultimately cell death. There is a strong causal relationship between ischemia/reperfusion (I/R) injury and mitochondrial dysfunction following liver resection and transplantation. Compared to young patients, elderly patients poorly tolerate I/R injury. Accumulation of abnormal mitochondria after I/R is more prominent in aged livers than in young counterparts. This review highlights how altered autophagy is mechanistically involved in age-dependent hypersensitivity to reperfusion injury.
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spelling pubmed-98169432023-01-07 Mitochondrial Autophagy in Ischemic Aged Livers Kim, Jae-Sung Chapman, William C. Lin, Yiing Cells Review Mitochondrial autophagy (mitophagy) is a central catabolic event for mitochondrial quality control. Defective or insufficient mitophagy, thus, can result in mitochondrial dysfunction, and ultimately cell death. There is a strong causal relationship between ischemia/reperfusion (I/R) injury and mitochondrial dysfunction following liver resection and transplantation. Compared to young patients, elderly patients poorly tolerate I/R injury. Accumulation of abnormal mitochondria after I/R is more prominent in aged livers than in young counterparts. This review highlights how altered autophagy is mechanistically involved in age-dependent hypersensitivity to reperfusion injury. MDPI 2022-12-16 /pmc/articles/PMC9816943/ /pubmed/36552847 http://dx.doi.org/10.3390/cells11244083 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Jae-Sung
Chapman, William C.
Lin, Yiing
Mitochondrial Autophagy in Ischemic Aged Livers
title Mitochondrial Autophagy in Ischemic Aged Livers
title_full Mitochondrial Autophagy in Ischemic Aged Livers
title_fullStr Mitochondrial Autophagy in Ischemic Aged Livers
title_full_unstemmed Mitochondrial Autophagy in Ischemic Aged Livers
title_short Mitochondrial Autophagy in Ischemic Aged Livers
title_sort mitochondrial autophagy in ischemic aged livers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816943/
https://www.ncbi.nlm.nih.gov/pubmed/36552847
http://dx.doi.org/10.3390/cells11244083
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AT chapmanwilliamc mitochondrialautophagyinischemicagedlivers
AT linyiing mitochondrialautophagyinischemicagedlivers

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