Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches

Cyclic GMP–AMP synthase (cGAS), a crucial innate immune sensor, recognizes cytosolic DNA and induces stimulator of interferon genes (STING) to produce type I interferon and other proinflammatory cytokines, thereby mediating innate immune signaling. The cGAS–STING pathway is involved in the regulatio...

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Autores principales: Ding, Jiao, Dai, Yijie, Zhu, Jiahui, Fan, Xuemei, Zhang, Hao, Tang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817143/
https://www.ncbi.nlm.nih.gov/pubmed/36618820
http://dx.doi.org/10.3389/fnmol.2022.1050837
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author Ding, Jiao
Dai, Yijie
Zhu, Jiahui
Fan, Xuemei
Zhang, Hao
Tang, Bo
author_facet Ding, Jiao
Dai, Yijie
Zhu, Jiahui
Fan, Xuemei
Zhang, Hao
Tang, Bo
author_sort Ding, Jiao
collection PubMed
description Cyclic GMP–AMP synthase (cGAS), a crucial innate immune sensor, recognizes cytosolic DNA and induces stimulator of interferon genes (STING) to produce type I interferon and other proinflammatory cytokines, thereby mediating innate immune signaling. The cGAS–STING pathway is involved in the regulation of infectious diseases, anti-tumor immunity, and autoimmune diseases; in addition, it plays a key role in the development of central nervous system (CNS) diseases. Therapeutics targeting the modulation of cGAS–STING have promising clinical applications. Here, we summarize the cGAS–STING signaling mechanism and the recent research on its role in CNS diseases.
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spelling pubmed-98171432023-01-07 Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches Ding, Jiao Dai, Yijie Zhu, Jiahui Fan, Xuemei Zhang, Hao Tang, Bo Front Mol Neurosci Molecular Neuroscience Cyclic GMP–AMP synthase (cGAS), a crucial innate immune sensor, recognizes cytosolic DNA and induces stimulator of interferon genes (STING) to produce type I interferon and other proinflammatory cytokines, thereby mediating innate immune signaling. The cGAS–STING pathway is involved in the regulation of infectious diseases, anti-tumor immunity, and autoimmune diseases; in addition, it plays a key role in the development of central nervous system (CNS) diseases. Therapeutics targeting the modulation of cGAS–STING have promising clinical applications. Here, we summarize the cGAS–STING signaling mechanism and the recent research on its role in CNS diseases. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9817143/ /pubmed/36618820 http://dx.doi.org/10.3389/fnmol.2022.1050837 Text en Copyright © 2022 Ding, Dai, Zhu, Fan, Zhang and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Ding, Jiao
Dai, Yijie
Zhu, Jiahui
Fan, Xuemei
Zhang, Hao
Tang, Bo
Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches
title Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches
title_full Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches
title_fullStr Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches
title_full_unstemmed Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches
title_short Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches
title_sort research advances in cgas–stimulator of interferon genes pathway and central nervous system diseases: focus on new therapeutic approaches
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817143/
https://www.ncbi.nlm.nih.gov/pubmed/36618820
http://dx.doi.org/10.3389/fnmol.2022.1050837
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