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Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain
Background: Because of the rising prevalence of anterior talofibular ligament (ATFL) damage, there is a considerable interest in developing innovative techniques to improve the biological healing response of ATFL. Platelet-rich plasma (PRP) includes several growth factors linked to a favorable heali...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817145/ https://www.ncbi.nlm.nih.gov/pubmed/36619392 http://dx.doi.org/10.3389/fbioe.2022.1073063 |
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author | Zhang, Jieyuan Wang, Cheng Li, Xueqian Fu, Shaoling Gu, Wenqi Shi, Zhongmin |
author_facet | Zhang, Jieyuan Wang, Cheng Li, Xueqian Fu, Shaoling Gu, Wenqi Shi, Zhongmin |
author_sort | Zhang, Jieyuan |
collection | PubMed |
description | Background: Because of the rising prevalence of anterior talofibular ligament (ATFL) damage, there is a considerable interest in developing innovative techniques to improve the biological healing response of ATFL. Platelet-rich plasma (PRP) includes several growth factors linked to a favorable healing response, however none of the studies involved both quality evaluation and clinical results to evaluate this treatment. Purpose: To determine the clinical results of PRP injections into the ATFL in lateral ankle sprain (LAS) patients, as well as the quality of the ATFL based on radiographic outcomes. Methods: Patients with clinically confirmed grade II LAS for the first time (n = 83) were examined. The clinical outcomes of three types of injection methods were evaluated: none, once within 48 h after the sprain, and once more 4 weeks later after first injection. PRP was injected into the tear site of the ATFL using ultrasound guidance, and all ankles were immobilized for 2 weeks. The American Orthopedic Foot and Ankle Score (AOFAS) ankle-hindfoot scale and the Visual Analogue Scale (VAS) were used to assess the results at 2, 6, 8, 24, and 48 weeks of follow-up. The signal/noise ratio (SNR) value of Magnetic Resonance Imaging (MRI)-based ATFL signal intensity can disclose ATFL quality. The ATFL SNR results were then assessed 8, 24 and 48 weeks following the first injection to compare ATFL quality. Results: The PRP injection groups outperformed the control group in terms of clinical outcomes, and the two injections group outperformed other groups in terms of pain reduction and functional outcome at 8 weeks. The clinical results of all groups were comparable at 6 and 12 months follow-up. ATFL SNR findings improved significantly across all groups over time. At the same follow-up time, the PRP injection groups outperformed the control group, and the best SNR result showed in the two injections group at the final follow-up. Conclusion: PRP injection helped relieve early symptoms of LAS, although all patients saw a similar development after 6 months. The two PRP injections group produced considerably better clinical results and quality of the ATFL in short-term follow-up. |
format | Online Article Text |
id | pubmed-9817145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98171452023-01-07 Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain Zhang, Jieyuan Wang, Cheng Li, Xueqian Fu, Shaoling Gu, Wenqi Shi, Zhongmin Front Bioeng Biotechnol Bioengineering and Biotechnology Background: Because of the rising prevalence of anterior talofibular ligament (ATFL) damage, there is a considerable interest in developing innovative techniques to improve the biological healing response of ATFL. Platelet-rich plasma (PRP) includes several growth factors linked to a favorable healing response, however none of the studies involved both quality evaluation and clinical results to evaluate this treatment. Purpose: To determine the clinical results of PRP injections into the ATFL in lateral ankle sprain (LAS) patients, as well as the quality of the ATFL based on radiographic outcomes. Methods: Patients with clinically confirmed grade II LAS for the first time (n = 83) were examined. The clinical outcomes of three types of injection methods were evaluated: none, once within 48 h after the sprain, and once more 4 weeks later after first injection. PRP was injected into the tear site of the ATFL using ultrasound guidance, and all ankles were immobilized for 2 weeks. The American Orthopedic Foot and Ankle Score (AOFAS) ankle-hindfoot scale and the Visual Analogue Scale (VAS) were used to assess the results at 2, 6, 8, 24, and 48 weeks of follow-up. The signal/noise ratio (SNR) value of Magnetic Resonance Imaging (MRI)-based ATFL signal intensity can disclose ATFL quality. The ATFL SNR results were then assessed 8, 24 and 48 weeks following the first injection to compare ATFL quality. Results: The PRP injection groups outperformed the control group in terms of clinical outcomes, and the two injections group outperformed other groups in terms of pain reduction and functional outcome at 8 weeks. The clinical results of all groups were comparable at 6 and 12 months follow-up. ATFL SNR findings improved significantly across all groups over time. At the same follow-up time, the PRP injection groups outperformed the control group, and the best SNR result showed in the two injections group at the final follow-up. Conclusion: PRP injection helped relieve early symptoms of LAS, although all patients saw a similar development after 6 months. The two PRP injections group produced considerably better clinical results and quality of the ATFL in short-term follow-up. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9817145/ /pubmed/36619392 http://dx.doi.org/10.3389/fbioe.2022.1073063 Text en Copyright © 2022 Zhang, Wang, Li, Fu, Gu and Shi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Zhang, Jieyuan Wang, Cheng Li, Xueqian Fu, Shaoling Gu, Wenqi Shi, Zhongmin Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain |
title | Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain |
title_full | Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain |
title_fullStr | Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain |
title_full_unstemmed | Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain |
title_short | Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain |
title_sort | platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817145/ https://www.ncbi.nlm.nih.gov/pubmed/36619392 http://dx.doi.org/10.3389/fbioe.2022.1073063 |
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