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Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder
We report the case of a 46-year-old patient who, after renal cancer surgery, developed a recurrent urinary tract infection that lasted for more than 2 years. Despite repeated antibiotic courses, including broad-spectrum drugs chosen using conventional antibiotic susceptibility testing, multiple rein...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817160/ https://www.ncbi.nlm.nih.gov/pubmed/36619660 http://dx.doi.org/10.1016/j.eucr.2022.102312 |
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author | Tetz, George V. Kardava, Kristina M. Vecherkovskaya, Maria F. Tsifansky, Michael D. Tetz, Victor V. |
author_facet | Tetz, George V. Kardava, Kristina M. Vecherkovskaya, Maria F. Tsifansky, Michael D. Tetz, Victor V. |
author_sort | Tetz, George V. |
collection | PubMed |
description | We report the case of a 46-year-old patient who, after renal cancer surgery, developed a recurrent urinary tract infection that lasted for more than 2 years. Despite repeated antibiotic courses, including broad-spectrum drugs chosen using conventional antibiotic susceptibility testing, multiple reinfections followed. The patient was successfully treated once antibiotics were selected with AtbFinder. Unlike routine antimicrobial susceptibility methods, which select antibiotics effective only against a “lead bacterial pathogen,” AtbFinder identifies antibiotics that target the mixture of bacteria at the infection site. This case demonstrates the ability of AtbFinder to successfully select antibiotics for the treatment of relapsing urinary tract infections. |
format | Online Article Text |
id | pubmed-9817160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-98171602023-01-07 Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder Tetz, George V. Kardava, Kristina M. Vecherkovskaya, Maria F. Tsifansky, Michael D. Tetz, Victor V. Urol Case Rep Inflammation and Infection We report the case of a 46-year-old patient who, after renal cancer surgery, developed a recurrent urinary tract infection that lasted for more than 2 years. Despite repeated antibiotic courses, including broad-spectrum drugs chosen using conventional antibiotic susceptibility testing, multiple reinfections followed. The patient was successfully treated once antibiotics were selected with AtbFinder. Unlike routine antimicrobial susceptibility methods, which select antibiotics effective only against a “lead bacterial pathogen,” AtbFinder identifies antibiotics that target the mixture of bacteria at the infection site. This case demonstrates the ability of AtbFinder to successfully select antibiotics for the treatment of relapsing urinary tract infections. Elsevier 2022-12-28 /pmc/articles/PMC9817160/ /pubmed/36619660 http://dx.doi.org/10.1016/j.eucr.2022.102312 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Inflammation and Infection Tetz, George V. Kardava, Kristina M. Vecherkovskaya, Maria F. Tsifansky, Michael D. Tetz, Victor V. Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder |
title | Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder |
title_full | Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder |
title_fullStr | Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder |
title_full_unstemmed | Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder |
title_short | Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder |
title_sort | treatment of chronic relapsing urinary tract infection with antibiotics selected by atbfinder |
topic | Inflammation and Infection |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817160/ https://www.ncbi.nlm.nih.gov/pubmed/36619660 http://dx.doi.org/10.1016/j.eucr.2022.102312 |
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