MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD

Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar degeneration (FTLD)-tau, which span a wide phenotypic and pathological spectrum. Some of these mutations, such as the N279K...

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Detalles Bibliográficos
Autores principales: Korn, Lisanne, Speicher, Anna M., Schroeter, Christina B., Gola, Lukas, Kaehne, Thilo, Engler, Alexander, Disse, Paul, Fernández-Orth, Juncal, Csatári, Júlia, Naumann, Michael, Seebohm, Guiscard, Meuth, Sven G., Schöler, Hans R., Wiendl, Heinz, Kovac, Stjepana, Pawlowski, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817175/
https://www.ncbi.nlm.nih.gov/pubmed/36599286
http://dx.doi.org/10.1016/j.redox.2022.102597

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