Cargando…

Codelivery of TGF-β1 and anti-miR-141 by PLGA microspheres inhibits progression of intervertebral disc degeneration

BACKGROUND: Cervical and lumbar pain is usually caused by degeneration of the nucleus pulposus (NP). As a powerful therapeutic strategy, tissue engineering can effectively restore the normal biological properties of the spinal unit. Previous studies suggested that poly(lactic-co-glycolic acid) (PLGA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Liang, Gao, Daokuan, Zhang, Yu, Liu, Chen, Yin, Zongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817358/ https://www.ncbi.nlm.nih.gov/pubmed/36609253 http://dx.doi.org/10.1186/s13018-023-03501-5

Ejemplares similares

An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration
por: Cheng, Haozhe, et al.
Publicado: (2022)

TGF-βl Suppresses Inflammation in Cell Therapy for Intervertebral Disc Degeneration
por: Yang, Huilin, et al.
Publicado: (2015)

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System
por: Guo, Taowen, et al.
Publicado: (2022)

Circ_0005918 Sponges miR-622 to Aggravate Intervertebral Disc Degeneration
por: Cui, Yan, et al.
Publicado: (2022)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

The Mechanism and Function of miRNA in Intervertebral Disc Degeneration
por: Wang, Chenglong, et al.
Publicado: (2022)

Role of miR‐155 in the regulation of MMP‐16 expression in intervertebral disc degeneration
por: Zhang, Wei‐Lin, et al.
Publicado: (2017)

Mechanism of protective role of miR-874-3p in intervertebral disc degeneration
por: Yang, Xuefang
Publicado: (2022)

Can Manganese Dioxide Microspheres be Used as Intermediaries to Alleviate Intervertebral Disc Degeneration With Strengthening Drugs?
por: Zhang, Wentao, et al.
Publicado: (2022)

Exosomes from M2c macrophages alleviate intervertebral disc degeneration by promoting synthesis of the extracellular matrix via MiR‐124/CILP/TGF‐β
por: Liu, Yi, et al.
Publicado: (2023)

Pathomechanism of intervertebral disc degeneration
por: Oichi, Takeshi, et al.
Publicado: (2020)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis
por: Bian, Qin, et al.
Publicado: (2017)

Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578
por: Yan, Peng, et al.
Publicado: (2022)

Ligustrazine Prevents Intervertebral Disc Degeneration via Suppression of Aberrant TGFβ Activation in Nucleus Pulposus Cells
por: Liu, Shufen, et al.
Publicado: (2019)

hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration
por: Chen, Dong, et al.
Publicado: (2023)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Effects of TGF-β1 and IL-1β on expression of ADAMTS enzymes and TIMP-3 in human intervertebral disc degeneration
por: WANG, SHI-LONG, et al.
Publicado: (2013)

The Role of miR-31-5p in the Development of Intervertebral Disc Degeneration and Its Therapeutic Potential
por: Zhou, Yong, et al.
Publicado: (2021)

miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2
por: Yan, Jing, et al.
Publicado: (2022)

hsa-miR-508-5p as a New Potential Player in Intervertebral Disc Degeneration
por: Gholipour, Akram, et al.
Publicado: (2022)

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
por: Munir, Sabrina, et al.
Publicado: (2018)

Angiogenesis in the degeneration of the lumbar intervertebral disc
por: David, Gh, et al.
Publicado: (2010)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Genetic factors in intervertebral disc degeneration
por: Feng, Yi, et al.
Publicado: (2016)

The Role of Adipokines in Intervertebral Disc Degeneration
por: Sharma, Anirudh
Publicado: (2018)

Molecular Mechanisms of Intervertebral Disc Degeneration
por: Rider, Sean M., et al.
Publicado: (2018)

Genetic Therapy for Intervertebral Disc Degeneration
por: Roh, Eun Ji, et al.
Publicado: (2021)

Cervical intervertebral disc degeneration and dizziness
por: Liu, Tang-Hua, et al.
Publicado: (2021)

The Proteolysis of ECM in Intervertebral Disc Degeneration
por: Liang, Huaizhen, et al.
Publicado: (2022)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Role of Necroptosis in Intervertebral Disc Degeneration
por: Khaleque, Md Abdul, et al.
Publicado: (2023)

The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration
por: Yao, Bo, et al.
Publicado: (2023)

The role of TGF‐β1/Smad2/3 pathway in platelet‐rich plasma in retarding intervertebral disc degeneration
por: Yang, Huilin, et al.
Publicado: (2016)

Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model
por: Zieba, Jennifer, et al.
Publicado: (2022)

Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis
por: Sun, Ruping, et al.
Publicado: (2023)

Identification and Verification of Key MiRNAs Associated with Intervertebral Disc Degeneration
por: Liu, Jianwei, et al.
Publicado: (2023)

Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration
por: Willems, Nicole, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qoogcqpejtu5hp62l3ue3h54mj