Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways

BACKGROUND: The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma during repeated muscle contractions. One integral componen...

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Detalles Bibliográficos
Autores principales: McCourt, Jackie L., Stearns-Reider, Kristen M., Mamsa, Hafsa, Kannan, Pranav, Afsharinia, Mohammad Hossein, Shu, Cynthia, Gibbs, Elizabeth M., Shin, Kara M., Kurmangaliyev, Yerbol Z., Schmitt, Lauren R., Hansen, Kirk C., Crosbie, Rachelle H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817407/
https://www.ncbi.nlm.nih.gov/pubmed/36609344
http://dx.doi.org/10.1186/s13395-022-00311-x

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